Seroatlas · Human Serome Atlas

NMI

N-myc-interactor

Also known as: NMI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13287
Gene
NMI
Ensembl
ENSG00000123609
Chromosome
2
Canonical length
307 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q13287|NMI
     1  MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL KKEIQKLETE LQEATKEFQI
    61  KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI QKGQALITFE KEEVAQNVVS
   121  MSKHHVQIKD VNLEVTAKPV PLNSGVRFQV YVEVSKMKIN VTEIPDTLRE DQMRDKLELS
   181  FSKSRNGGGE VDRVDYDRQS GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE
   241  IHLKKYQIFS GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP
   301  HIAYFEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 70 nTPM
  • spleen: 45 nTPM
  • appendix: 42 nTPM
  • thymus: 41 nTPM
  • lymph node: 41 nTPM
  • liver: 33 nTPM

Single-cell type

  • neutrophils: 260 nCPM
  • megakaryocytes: 161 nCPM
  • migrating cytotrophoblasts: 122 nCPM
  • neutrophil progenitors: 113 nCPM
  • megakaryocyte progenitors: 106 nCPM
  • megakaryocyte-erythroid progenitors: 97 nCPM

Immune cell

  • neutrophil: 469 nTPM
  • basophil: 253 nTPM
  • intermediate monocyte: 173 nTPM
  • non-classical monocyte: 171 nTPM
  • eosinophil: 141 nTPM
  • classical monocyte: 122 nTPM

Brain region

  • medulla oblongata: 7.7 nTPM
  • spinal cord: 6.5 nTPM
  • white matter: 6.4 nTPM
  • thalamus: 5.9 nTPM
  • midbrain: 5.7 nTPM
  • hypothalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NMI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMI as an antibody target. Whether an autoantibody or antibody against NMI could matter depends on whether native NMI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMI is annotated as secreted, so native NMI circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NMI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NMI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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