Seroatlas · Human Serome Atlas

TRAK1

Trafficking kinesin-binding protein 1

Also known as: KIAA1042, MILT1, OIP106, TRAK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPV9
Gene
TRAK1
Ensembl
ENSG00000182606
Chromosome
3
Canonical length
953 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable GABA receptor binding activity and myosin binding activity. Involved in endosome to lysosome transport. Located in early endosome and mitochondrion. Implicated in developmental and epileptic encephalopathy 68. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q9UPV9|TRAK1
     1  MALVFQFGQP VRAQPLPGLC HGKLIRTNAC DVCNSTDLPE VEIISLLEEQ LPHYKLRADT
    61  IYGYDHDDWL HTPLISPDAN IDLTTEQIEE TLKYFLLCAE RVGQMTKTYN DIDAVTRLLE
   121  EKERDLELAA RIGQSLLKKN KTLTERNELL EEQVEHIREE VSQLRHELSM KDELLQFYTS
   181  AAEESEPESV CSTPLKRNES SSSVQNYFHL DSLQKKLKDL EEENVVLRSE ASQLKTETIT
   241  YEEKEQQLVN DCVKELRDAN VQIASISEEL AKKTEDAARQ QEEITHLLSQ IVDLQKKAKA
   301  CAVENEELVQ HLGAAKDAQR QLTAELRELE DKYAECMEML HEAQEELKNL RNKTMPNTTS
   361  RRYHSLGLFP MDSLAAEIEG TMRKELQLEE AESPDITHQK RVFETVRNIN QVVKQRSLTP
   421  SPMNIPGSNQ SSAMNSLLSS CVSTPRSSFY GSDIGNVVLD NKTNSIILET EAADLGNDER
   481  SKKPGTPGTP GSHDLETALR RLSLRRENYL SERRFFEEEQ ERKLQELAEK GELRSGSLTP
   541  TESIMSLGTH SRFSEFTGFS GMSFSSRSYL PEKLQIVKPL EGSATLHHWQ QLAQPHLGGI
   601  LDPRPGVVTK GFRTLDVDLD EVYCLNDFEE DDTGDHISLP RLATSTPVQH PETSAHHPGK
   661  CMSQTNSTFT FTTCRILHPS DELTRVTPSL NSAPTPACGS TSHLKSTPVA TPCTPRRLSL
   721  AESFTNTRES TTTMSTSLGL VWLLKERGIS AAVYDPQSWD RAGRGSLLHS YTPKMAVIPS
   781  TPPNSPMQTP TSSPPSFEFK CTSPPYDNFL ASKPASSILR EVREKNVRSS ESQTDVSVSN
   841  LNLVDKVRRF GVAKVVNSGR AHVPTLTEEQ GPLLCGPPGP APALVPRGLV PEGLPLRCPT
   901  VTSAIGGLQL NSGIRRNRSF PTMVGSSMQM KAPVTLTSGI LMGAKLSKQT SLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
246 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 246 nTPM
  • tongue: 189 nTPM
  • heart muscle: 158 nTPM
  • retina: 90 nTPM
  • stomach: 58 nTPM
  • skin: 43 nTPM

Single-cell type

  • renal connecting tubule cells: 448 nCPM
  • neutrophils: 437 nCPM
  • myonuclei: 422 nCPM
  • rod photoreceptor cells: 319 nCPM
  • cardiomyocytes: 308 nCPM
  • b-cells: 308 nCPM

Immune cell

  • naive B-cell: 3.6 nTPM
  • plasmacytoid DC: 2.5 nTPM
  • intermediate monocyte: 2.4 nTPM
  • memory B-cell: 2.4 nTPM
  • myeloid DC: 1.5 nTPM
  • non-classical monocyte: 1.4 nTPM

Brain region

  • midbrain: 86 nTPM
  • choroid plexus: 79 nTPM
  • cerebellum: 78 nTPM
  • cerebral cortex: 76 nTPM
  • thalamus: 74 nTPM
  • medulla oblongata: 72 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAK1.

Disease | AllUniProt

Conditions TRAK1 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 68 (DEE68) MIM:618201

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 382 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAK1 as an antibody target. Whether an autoantibody or antibody against TRAK1 could matter depends on whether native TRAK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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