Seroatlas · Human Serome Atlas

EXOC7

Exocyst complex component 7

Also known as: BLOM4, EXO70, Exo70p, EXOC7_HUMAN, KIAA1067, YJL085W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPT5
Gene
EXOC7
Ensembl
ENSG00000182473
Chromosome
17
Canonical length
735 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

735 residues, UniProt reviewed canonical sequence.

>Q9UPT5|EXOC7
     1  MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI
    61  IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ
   121  KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL
   181  EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK
   241  SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE
   301  GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL AGRDDMLDVE
   361  TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ DALDGLMLEG ENIVSAARKA
   421  IVRHDFSTVL TVFPILRHLK QTKPEFDQVL QGTAASTKNK LPGLITSMET IGAKALEDFA
   481  DNIKNDPDKE YNMPKDGTVH ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF
   541  SKRLLSTYIC KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT
   601  QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ IIKERFKGFN
   661  DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL QKFGSVPFTK NPEKYIKYGV
   721  EQVGDMIDRL FDTSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 58 nTPM
  • bone marrow: 50 nTPM
  • fallopian tube: 49 nTPM
  • esophagus: 49 nTPM
  • salivary gland: 48 nTPM
  • prostate: 45 nTPM

Single-cell type

  • esophageal apical cells: 180 nCPM
  • tuft cells: 138 nCPM
  • pituitary stem cells: 82 nCPM
  • syncytiotrophoblasts: 82 nCPM
  • late spermatids: 80 nCPM
  • fallopian tube ciliated cells: 79 nCPM

Immune cell

  • non-classical monocyte: 80 nTPM
  • eosinophil: 66 nTPM
  • intermediate monocyte: 57 nTPM
  • basophil: 55 nTPM
  • neutrophil: 46 nTPM
  • total PBMC: 45 nTPM

Brain region

  • pons: 70 nTPM
  • hippocampal formation: 69 nTPM
  • cerebral cortex: 68 nTPM
  • hypothalamus: 68 nTPM
  • basal ganglia: 67 nTPM
  • medulla oblongata: 67 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOC7.

Disease | AllUniProt

Conditions EXOC7 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with seizures and brain atrophy (NEDSEBA) MIM:619072

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
1.88
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC7 as an antibody target. Whether an autoantibody or antibody against EXOC7 could matter depends on whether native EXOC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC7 is annotated at the cell surface, where native EXOC7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EXOC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOC7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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