Seroatlas · Human Serome Atlas

POGLUT3

Protein O-glucosyltransferase 3

Also known as: KDELC2, MGC33424, PLGT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4H8
Gene
POGLUT3
Ensembl
ENSG00000178202
Chromosome
11
Canonical length
507 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q7Z4H8|POGLUT3
     1  MRRLPRALLL QLRLALLVAA GAPEVLVSAP RSLVWGPGLQ AAVVLPVRYF YLQAVNSEGQ
    61  NLTRSPAGET PFKVVVKSLS PKELVRIHVP KPLDRNDGTF LMRYRMYETV DEGLKIEVLY
   121  GDEHVAQSPY ILKGPVYHEY CECPEDPQAW QKTLSCPTKE PQIAKDFASF PSINLQQMLK
   181  EVPKRFGDER GAIVHYTILN NHVYRRSLGK YTDFKMFSDE ILLSLTRKVL LPDLEFYVNL
   241  GDWPLEHRKV NGTPSPIPII SWCGSLDSRD VVLPTYDITH SMLEAMRGVT NDLLSIQGNT
   301  GPSWINKTER AFFRGRDSRE ERLQLVQLSK ENPQLLDAGI TGYFFFQEKE KELGKAKLMG
   361  FFDFFKYKYQ VNVDGTVAAY RYPYLMLGDS LVLKQDSPYY EHFYMALEPW KHYVPIKRNL
   421  SDLLEKVKWA KENDEEAKKI AKEGQLMARD LLQPHRLYCY YYQVLQKYAE RQSSKPEVRD
   481  GMELVPQPED STAICQCHRK KPSREEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POGLUT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 35 nTPM
  • ovary: 34 nTPM
  • endometrium: 33 nTPM
  • cervix: 32 nTPM
  • blood vessel: 31 nTPM
  • placenta: 31 nTPM

Single-cell type

  • respiratory deuterosomal cells: 99 nCPM
  • distal convoluted tubule cells: 52 nCPM
  • hepatic stellate cells: 45 nCPM
  • fibroblasts: 44 nCPM
  • smooth muscle cells: 39 nCPM
  • cytotrophoblasts: 37 nCPM

Immune cell

  • gdT-cell: 2.1 nTPM
  • NK-cell: 2 nTPM
  • memory CD8 T-cell: 1.8 nTPM
  • MAIT T-cell: 1.7 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • memory CD4 T-cell: 1 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • midbrain: 9.2 nTPM
  • hypothalamus: 9 nTPM
  • white matter: 8.5 nTPM
  • medulla oblongata: 8.2 nTPM
  • spinal cord: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POGLUT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POGLUT3 as an antibody target. Whether an autoantibody or antibody against POGLUT3 could matter depends on whether native POGLUT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POGLUT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POGLUT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POGLUT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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