SEC11A
Signal peptidase complex catalytic subunit SEC11A
Also known as: SC11A_HUMAN, SEC11L1, sid2895, SPC18, SPCS4A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P67812
- Gene
- SEC11A
- Ensembl
- ENSG00000140612
- Chromosome
- 15
- Canonical length
- 179 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nuclear membrane,Golgi apparatus
OverviewNCBI Gene
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>P67812|SEC11A
1 MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV VVLSGSMEPA
61 FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK IHEKQNGHIK FLTKGDNNAV
121 DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG IVTILMNDYP KFKYAVLFLL GLFVLVHRELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 191 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 191 nTPM
- thyroid gland: 166 nTPM
- bone marrow: 162 nTPM
- ovary: 162 nTPM
- skeletal muscle: 158 nTPM
- adipose tissue: 155 nTPM
Single-cell type
- extravillous trophoblasts: 865 nCPM
- decidual stromal cells: 523 nCPM
- migrating cytotrophoblasts: 482 nCPM
- epididymal principal cells: 432 nCPM
- hofbauer cells: 404 nCPM
- gastric progenitor cells: 377 nCPM
Immune cell
- total PBMC: 201 nTPM
- non-classical monocyte: 186 nTPM
- intermediate monocyte: 174 nTPM
- T-reg: 169 nTPM
- myeloid DC: 166 nTPM
- classical monocyte: 161 nTPM
Brain region
- choroid plexus: 59 nTPM
- medulla oblongata: 55 nTPM
- white matter: 54 nTPM
- hypothalamus: 52 nTPM
- spinal cord: 51 nTPM
- thalamus: 46 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.99
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.58
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SEC11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC11A as an antibody target. Whether an autoantibody or antibody against SEC11A could matter depends on whether native SEC11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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