Seroatlas · Human Serome Atlas

EPDR1

Mammalian ependymin-related protein 1

Also known as: EPDR, EPDR1_HUMAN, MERP-1, MERP1, UCC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UM22
Gene
EPDR1
Ensembl
ENSG00000086289
Chromosome
7
Canonical length
224 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9UM22|EPDR1
     1  MPGRAPLRTV PGALGAWLLG GLWAWTLCGL CSLGAVGAPR PCQAPQQWEG RQVMYQQSSG
    61  RNSRALLSYD GLNQRVRVLD ERKALIPCKR LFEYILLYKD GVMFQIDQAT KQCSKMTLTQ
   121  PWDPLDIPQN STFEDQYSIG GPQEQITVQE WSDRKSARSY ETWIGIYTVK DCYPVQETFT
   181  INYSVILSTR FFDIQLGIKD PSVFTPPSTC QMAQLEKMSE DCSW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPDR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 114 nTPM
  • cerebellum: 76 nTPM
  • tongue: 67 nTPM
  • hypothalamus: 58 nTPM
  • cerebral cortex: 53 nTPM
  • blood vessel: 50 nTPM

Single-cell type

  • epididymal clear cells: 106 nCPM
  • other brain neurons: 92 nCPM
  • peritubular myoid cells: 84 nCPM
  • alveolar cells type 2: 80 nCPM
  • brain excitatory neurons: 69 nCPM
  • epididymal efferent duct ciliated cells: 64 nCPM

Immune cell

  • plasmacytoid DC: 2.2 nTPM
  • NK-cell: 0.8 nTPM
  • gdT-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • pons: 176 nTPM
  • cerebral cortex: 173 nTPM
  • hypothalamus: 146 nTPM
  • medulla oblongata: 121 nTPM
  • spinal cord: 112 nTPM
  • midbrain: 111 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0.02
gnomAD missense Z
-0.41
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ependymin
  • Ependymin, conserved site
  • Ependymin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPDR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPDR1 as an antibody target. Whether an autoantibody or antibody against EPDR1 could matter depends on whether native EPDR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPDR1 is annotated as secreted, so native EPDR1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EPDR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPDR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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