Seroatlas · Human Serome Atlas

PRCP

Lysosomal Pro-X carboxypeptidase

Also known as: HUMPCP, PCP, PCP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42785
Gene: PRCP
Ensembl: ENSG00000137509
Chromosome: 11
Canonical length: 496 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>P42785|PRCP
     1  MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF
    61  GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA
   121  EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY
   181  GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS
   241  WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP
   301  LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS
   361  YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT
   421  NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH
   481  MKNWIRDFYD SAGKQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 158 nTPM
placenta: 144 nTPM
liver: 142 nTPM
kidney: 135 nTPM
adrenal gland: 102 nTPM
urinary bladder: 94 nTPM

Single-cell type

kupffer cells: 375 nCPM
neutrophils: 328 nCPM
bergmann glia: 244 nCPM
vascular endothelial cells: 214 nCPM
cdc: 210 nCPM
extravillous trophoblasts: 190 nCPM

Immune cell

myeloid DC: 140 nTPM
neutrophil: 90 nTPM
intermediate monocyte: 79 nTPM
classical monocyte: 77 nTPM
non-classical monocyte: 65 nTPM
basophil: 54 nTPM

Brain region

choroid plexus: 66 nTPM
spinal cord: 55 nTPM
white matter: 47 nTPM
thalamus: 47 nTPM
hypothalamus: 47 nTPM
cerebellum: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRCP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FBXO6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRCP as an antibody target. Whether an autoantibody or antibody against PRCP could matter depends on whether native PRCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRCP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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