Seroatlas · Human Serome Atlas

EMC7

Endoplasmic reticulum membrane protein complex subunit 7

Also known as: C11orf3, C15orf24, EMC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPA0
Gene: EMC7
Ensembl: ENSG00000134153
Chromosome: 15
Canonical length: 242 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9NPA0|EMC7
     1  MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD
    61  WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA
   121  RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP
   181  KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK
   241  RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 143 nTPM
epididymis: 99 nTPM
liver: 97 nTPM
skeletal muscle: 94 nTPM
parathyroid gland: 88 nTPM
midbrain: 86 nTPM

Single-cell type

late primary spermatocytes: 324 nCPM
decidual stromal cells: 209 nCPM
extravillous trophoblasts: 206 nCPM
syncytiotrophoblasts: 186 nCPM
early primary spermatocytes: 174 nCPM
epididymal principal cells: 170 nCPM

Immune cell

basophil: 317 nTPM
plasmacytoid DC: 243 nTPM
non-classical monocyte: 207 nTPM
total PBMC: 196 nTPM
T-reg: 196 nTPM
intermediate monocyte: 184 nTPM

Brain region

choroid plexus: 82 nTPM
white matter: 71 nTPM
hypothalamus: 69 nTPM
cerebellum: 63 nTPM
spinal cord: 62 nTPM
pons: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.87
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Carbohydrate-binding-like fold
ER membrane protein complex subunit 7, beta-sandwich domain
ER membrane protein complex subunit 7
ER membrane protein complex subunit 7, beta-sandwich domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMC7 as an antibody target. Whether an autoantibody or antibody against EMC7 could matter depends on whether native EMC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EMC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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