F-box associated (FBA) domain

Definition

F-box proteins have a bipartite structure: they contain a carboxy-terminal domain that interacts with substrates and a 42-48 amino-acid F-box domain which binds to the protein Skp1. A subset of F-box proteins is characterised by a ~180-residue carboxy-terminal region, which has been called the F-box-associated (FBA) domain [[cite:PMID:10531037], [cite:PMID:12383498]]. A FBA domain has also been identified in the catfish, tilapia, and zebrafish nonspecific cytotoxic cell receptor proteins (NCCRP-1), which do not contain the F-box domain. NCCRP-1 may function as an antigen recognition molecule and, as such, may participate in innate immunity in teleosts [[cite:PMID:12383498], [cite:PMID:11847564]]. The FBA domain is likely to be a glycoprotein-binding module [[cite:PMID:12939278], [cite:PMID:14990996]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• FBXO17
• FBXO2
• FBXO27
• FBXO44
• FBXO6
• NCCRP1