Seroatlas · Human Serome Atlas

LOXL2

Lysyl oxidase homolog 2

Also known as: LOR, LOXL2_HUMAN, WS9-14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4K0
Gene
LOXL2
Ensembl
ENSG00000134013
Chromosome
8
Canonical length
774 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

774 residues, UniProt reviewed canonical sequence.

>Q9Y4K0|LOXL2
     1  MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL
    61  AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL GYVEAKSWTA SSSYGKGEGP
   121  IWLDNLHCTG NEATLAACTS NGWGVTDCKH TEDVGVVCSD KRIPGFKFDN SLINQIENLN
   181  IQVEDIRIRA ILSTYRKRTP VMEGYVEVKE GKTWKQICDK HWTAKNSRVV CGMFGFPGER
   241  TYNTKVYKMF ASRRKQRYWP FSMDCTGTEA HISSCKLGPQ VSLDPMKNVT CENGLPAVVS
   301  CVPGQVFSPD GPSRFRKAYK PEQPLVRLRG GAYIGEGRVE VLKNGEWGTV CDDKWDLVSA
   361  SVVCRELGFG SAKEAVTGSR LGQGIGPIHL NEIQCTGNEK SIIDCKFNAE SQGCNHEEDA
   421  GVRCNTPAMG LQKKLRLNGG RNPYEGRVEV LVERNGSLVW GMVCGQNWGI VEAMVVCRQL
   481  GLGFASNAFQ ETWYWHGDVN SNKVVMSGVK CSGTELSLAH CRHDGEDVAC PQGGVQYGAG
   541  VACSETAPDL VLNAEMVQQT TYLEDRPMFM LQCAMEENCL SASAAQTDPT TGYRRLLRFS
   601  SQIHNNGQSD FRPKNGRHAW IWHDCHRHYH SMEVFTHYDL LNLNGTKVAE GHKASFCLED
   661  TECEGDIQKN YECANFGDQG ITMGCWDMYR HDIDCQWVDI TDVPPGDYLF QVVINPNFEV
   721  AESDYSNNIM KCRSRYDGHR IWMYNCHIGG SFSEETEKKF EHFSGLLNNQ LSPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LOXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 39 nTPM
  • placenta: 34 nTPM
  • adipose tissue: 29 nTPM
  • colon: 24 nTPM
  • ovary: 19 nTPM
  • breast: 18 nTPM

Single-cell type

  • oocytes: 322 nCPM
  • hepatic stellate cells: 265 nCPM
  • pericytes: 118 nCPM
  • smooth muscle cells: 102 nCPM
  • ovarian stromal cells: 99 nCPM
  • vascular endothelial cells: 94 nCPM

Immune cell

  • eosinophil: 0.8 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • gdT-cell: 0.4 nTPM
  • memory B-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM

Brain region

  • midbrain: 19 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 17 nTPM
  • thalamus: 13 nTPM
  • cerebellum: 12 nTPM
  • spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LOXL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LOXL2 as an antibody target. Whether an autoantibody or antibody against LOXL2 could matter depends on whether native LOXL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LOXL2 is annotated as secreted, so native LOXL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LOXL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LOXL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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