Seroatlas · Human Serome Atlas

PCYOX1

Prenylcysteine oxidase 1

Also known as: KIAA0908, PCL1, PCYOX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHG3
Gene
PCYOX1
Ensembl
ENSG00000116005
Chromosome
2
Canonical length
505 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9UHG3|PCYOX1
     1  MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD
    61  VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLHMK RFVKDLGLSA VQASGGLLGI
   121  YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE
   181  KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL
   241  SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKYTGNPT KMYEVVYQIG
   301  TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR
   361  PIDKFGLNTV LTTDNSDLFI NSIGIVPSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK
   421  LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL
   481  AYHRWNGHTD MIDQDGLYEK LKTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCYOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • liver: 97 nTPM
  • kidney: 86 nTPM
  • skeletal muscle: 86 nTPM
  • adipose tissue: 74 nTPM
  • salivary gland: 66 nTPM
  • parathyroid gland: 62 nTPM

Single-cell type

  • alveolar cells type 1: 231 nCPM
  • hepatocytes: 220 nCPM
  • salivary acinar cells: 181 nCPM
  • retinal pigment epithelial cells: 175 nCPM
  • esophageal apical cells: 161 nCPM
  • prostatic glandular cells: 160 nCPM

Immune cell

  • basophil: 16 nTPM
  • naive CD4 T-cell: 11 nTPM
  • MAIT T-cell: 10 nTPM
  • naive CD8 T-cell: 9.2 nTPM
  • gdT-cell: 8.2 nTPM
  • memory CD4 T-cell: 8 nTPM

Brain region

  • choroid plexus: 82 nTPM
  • hypothalamus: 79 nTPM
  • pons: 73 nTPM
  • midbrain: 67 nTPM
  • medulla oblongata: 55 nTPM
  • cerebral cortex: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
-0.07
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCYOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCYOX1 as an antibody target. Whether an autoantibody or antibody against PCYOX1 could matter depends on whether native PCYOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCYOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCYOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCYOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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