Seroatlas · Human Serome Atlas

PCYOX1L

Prenylcysteine oxidase 1-like

Also known as: MGC3265, PCYXL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBM8
Gene: PCYOX1L
Ensembl: ENSG00000145882
Chromosome: 5
Canonical length: 494 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Mitochondria
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable prenylcysteine oxidase activity. Predicted to be involved in prenylated protein catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q8NBM8|PCYOX1L
     1  MARAAPLLAA LTALLAAAAA GGDAPPGKIA VVGAGIGGSA VAHFLQQHFG PRVQIDVYEK
    61  GTVGGRLATI SVNKQHYESG AASFHSLSLH MQDFVKLLGL RHRREVVGRS AIFGGEHFML
   121  EETDWYLLNL FRLWWHYGIS FLRLQMWVEE VMEKFMRIYK YQAHGYAFSG VEELLYSLGE
   181  STFVNMTQHS VAESLLQVGV TQRFIDDVVS AVLRASYGQS AAMPAFAGAM SLAGAQGSLW
   241  SVEGGNKLVC SGLLKLTKAN VIHATVTSVT LHSTEGKALY QVAYENEVGN SSDFYDIVVI
   301  ATPLHLDNSS SNLTFAGFHP PIDDVQGSFQ PTVVSLVHGY LNSSYFGFPD PKLFPFANIL
   361  TTDFPSFFCT LDNICPVNIS ASFRRKQPQE AAVWRVQSPK PLFRTQLKTL FRSYYSVQTA
   421  EWQAHPLYGS RPTLPRFALH DQLFYLNALE WAASSVEVMA VAAKNVALLA YNRWYQDLDK
   481  IDQKDLMHKV KTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCYOX1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 16 nTPM
cerebellum: 13 nTPM
cerebral cortex: 10 nTPM
testis: 8.2 nTPM
hypothalamus: 8 nTPM
retina: 7 nTPM

Single-cell type

oocytes: 28 nCPM
platelets: 14 nCPM
other brain neurons: 14 nCPM
megakaryocyte progenitors: 13 nCPM
thyrotrophs: 13 nCPM
brain inhibitory neurons: 13 nCPM

Immune cell

myeloid DC: 13 nTPM
intermediate monocyte: 9.6 nTPM
non-classical monocyte: 9.6 nTPM
T-reg: 7.3 nTPM
classical monocyte: 7.1 nTPM
naive CD4 T-cell: 6.3 nTPM

Brain region

pons: 15 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 14 nTPM
medulla oblongata: 12 nTPM
midbrain: 9.7 nTPM
cerebellum: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

prenylcysteine oxidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCYOX1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCYOX1L as an antibody target. Whether an autoantibody or antibody against PCYOX1L could matter depends on whether native PCYOX1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCYOX1L is annotated as secreted, so native PCYOX1L circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PCYOX1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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