Seroatlas · Human Serome Atlas

ARSK

Arylsulfatase K

Also known as: ARSK_HUMAN, DKFZp313G1735, TSULF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWY0
Gene
ARSK
Ensembl
ENSG00000164291
Chromosome
5
Canonical length
536 aa
Protein class
Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>Q6UWY0|ARSK
     1  MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP GSQVVKLPFI
    61  NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN NFKGLDPNYT TWMDVMERHG
   121  YRTQKFGKLD YTSGHHSISN RVEAWTRDVA FLLRQEGRPM VNLIRNRTKV RVMERDWQNT
   181  DKAVNWLRKE AINYTEPFVI YLGLNLPHPY PSPSSGENFG SSTFHTSLYW LEKVSHDAIK
   241  IPKWSPLSEM HPVDYYSSYT KNCTGRFTKK EIKNIRAFYY AMCAETDAML GEIILALHQL
   301  DLLQKTIVIY SSDHGELAME HRQFYKMSMY EASAHVPLLM MGPGIKAGLQ VSNVVSLVDI
   361  YPTMLDIAGI PLPQNLSGYS LLPLSSETFK NEHKVKNLHP PWILSEFHGC NVNASTYMLR
   421  TNHWKYIAYS DGASILPQLF DLSSDPDELT NVAVKFPEIT YSLDQKLHSI INYPKVSASV
   481  HQYNKEQFIK WKQSIGQNYS NVIANLRWHQ DWQKEPRKYE NAIDQWLKTH MNPRAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 18 nTPM
  • ovary: 5.3 nTPM
  • placenta: 5.1 nTPM
  • kidney: 5 nTPM
  • seminal vesicle: 4.7 nTPM
  • pancreas: 4.6 nTPM

Single-cell type

  • extravillous trophoblasts: 88 nCPM
  • prostatic glandular cells: 49 nCPM
  • basal prostatic cells: 39 nCPM
  • mast cells: 38 nCPM
  • platelets: 30 nCPM
  • renal collecting duct intercalated cells: 29 nCPM

Immune cell

  • basophil: 13 nTPM
  • naive CD4 T-cell: 7 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • naive CD8 T-cell: 5.2 nTPM
  • naive B-cell: 5 nTPM
  • memory B-cell: 4.8 nTPM

Brain region

  • cerebellum: 6.6 nTPM
  • hypothalamus: 6.5 nTPM
  • hippocampal formation: 5.9 nTPM
  • cerebral cortex: 5.8 nTPM
  • pons: 5.8 nTPM
  • basal ganglia: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARSK.

Disease | AllUniProt

Conditions ARSK is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 100 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mucopolysaccharidosis, type 10

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.25
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARSK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSK as an antibody target. Whether an autoantibody or antibody against ARSK could matter depends on whether native ARSK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSK is annotated as secreted, so native ARSK circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ARSK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARSK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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