NOMO3

Protein identityUniProt · HPA

UniProt accession

P69849

Gene

NOMO3

Ensembl

ENSG00000103226

Chromosome

16

Canonical length

1222 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1222 residues, UniProt reviewed canonical sequence.

>P69849|NOMO3
     1  MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN YSLIEIKLYT
    61  KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF EPTTVELHVD GVSDICTKGG
   121  DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD
   181  YEILATHPTW ALKEASTTVR VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS
   241  LVTKEDVLGC NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
   301  TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT LNNQIKVKTK
   361  ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL ADIVATGFSV CGQISIIRFP
   421  DTVKQMNKYK VVLSSQDKDK SLVTVETDAH GSFCFKANPG TYKVQVMVPE AETRAGLTLK
   481  PQTFPLTVTD RPVMDVAFVQ FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV
   541  NAMTFTFDNV LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI
   601  TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT YDTSSPSILT
   661  LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK SVQELRREQQ LAEIEARRQE
   721  REKNGNEEGE ERMTKPPVQE MVDELQGPFS YDFSYWARSG EKITVTPSSK ELLFYPPSME
   781  AVVSGESCPG KLIEIHGKAG LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV
   841  GPLHSDLEYT VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
   901  LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL KITITGYRTA
   961  YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE GKFRLRGLLP GCVYHVQLKA
  1021  EGNDHIERAL PHHRVIEVGN NDIDDVNIIV FRQINQFDLS GNVITSSEYL PTLWVKLYKS
  1081  ENLDNPIQTV SLGQSLFFHF PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH
  1141  ITLIFNPTRK LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA
  1201  ASDNSGPEDA KRQAKKQKTR RT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOMO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

5.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.81

gnomAD pLI

0

gnomAD missense Z

1.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• determination of left/right asymmetry in lateral mesoderm
• multi-pass transmembrane protein insertion into ER membrane
• negative regulation of nodal signaling pathway

Molecular functions

• carbohydrate binding
• ribosome binding

Cellular components

• endoplasmic reticulum membrane
• multi-pass translocon complex

Protein domainsUniProt · Pfam · InterPro

• Carboxypeptidase-like, regulatory domain superfamily
• Immunoglobulin-like fold
• Carbohydrate-binding-like fold
• SpaA-like, prealbumin fold domain subgroup 1
• Serine-Aspartate Repeat-Containing
• NOMO-like, ninth beta-sandwich domain
• NOMO-like, N-terminal beta-sandwich domain
• NOMO, eighth prealbumin-like domain
• NOMO, third transthyretin-like domain
• NOMO, fifth transthyretin-like domain
• NOMO, C-terminal transthyretin-like domain
• NOMO, seventh transthyretin-like domain
• Carboxypeptidase regulatory-like domain
• Prealbumin-like fold domain
• BOS complex subunit NOMO1-like, first beta sandwich domain
• BOS complex subunit NOMO1-like, beta sandwich domain
• BOS complex subunit NOMO1-like, second beta sandwich domain
• NOMO Ig-like domain
• NOMO C-terminal transthyretin-like domain
• NOMO third transthyretin-like domain
• NOMO fifth transthyretin-like domain
• NOMO eighth prealbumin-like domain

KeywordsUniProt

• Endoplasmic reticulum
• Glycoprotein
• Membrane
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of NOMO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBXO6