Seroatlas · Human Serome Atlas

ATMIN

ATM interactor

Also known as: ASCIZ, ATMIN_HUMAN, KIAA0431, ZNF822

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43313
Gene: ATMIN
Ensembl: ENSG00000166454
Chromosome: 16
Canonical length: 823 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Enables dynein complex binding activity. Involved in positive regulation of DNA-templated transcription. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>O43313|ATMIN
     1  MAASEAAAAA GSAALAAGAR AVPAATTGAA AAASGPWVPP GPRLRGSRPR PAGATQQPAV
    61  PAPPAGELIQ PSVSELSRAV RTNILCTVRG CGKILPNSPA LNMHLVKSHR LQDGIVNPTI
   121  RKDLKTGPKF YCCPIEGCPR GPERPFSQFS LVKQHFMKMH AEKKHKCSKC SNSYGTEWDL
   181  KRHAEDCGKT FRCTCGCPYA SRTALQSHIY RTGHEIPAEH RDPPSKKRKM ENCAQNQKLS
   241  NKTIESLNNQ PIPRPDTQEL EASEIKLEPS FEDSCGSNTD KQTLTTPPRY PQKLLLPKPK
   301  VALVKLPVMQ FSVMPVFVPT ADSSAQPVVL GVDQGSATGA VHLMPLSVGT LILGLDSEAC
   361  SLKESLPLFK IANPIAGEPI STGVQVNFGK SPSNPLQELG NTCQKNSISS INVQTDLSYA
   421  SQNFIPSAQW ATADSSVSSC SQTDLSFDSQ VSLPISVHTQ TFLPSSKVTS SIAAQTDAFM
   481  DTCFQSGGVS RETQTSGIES PTDDHVQMDQ AGMCGDIFES VHSSYNVATG NIISNSLVAE
   541  TVTHSLLPQN EPKTLNQDIE KSAPIINFSA QNSMLPSQNM TDNQTQTIDL LSDLENILSS
   601  NLPAQTLDHR SLLSDTNPGP DTQLPSGPAQ NPGIDFDIEE FFSASNIQTQ TEESELSTMT
   661  TEPVLESLDI ETQTDFLLAD TSAQSYGCRG NSNFLGLEMF DTQTQTDLNF FLDSSPHLPL
   721  GSILKHSSFS VSTDSSDTET QTEGVSTAKN IPALESKVQL NSTETQTMSS GFETLGSLFF
   781  TSNETQTAMD DFLLADLAWN TMESQFSSVE TQTSAEPHTV SNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATMIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 25 nTPM
cerebral cortex: 22 nTPM
testis: 21 nTPM
hypothalamus: 20 nTPM
amygdala: 20 nTPM
thyroid gland: 19 nTPM

Single-cell type

late spermatids: 438 nCPM
early spermatids: 225 nCPM
esophageal apical cells: 91 nCPM
retinal pigment epithelial cells: 85 nCPM
prostatic glandular cells: 54 nCPM
late primary spermatocytes: 53 nCPM

Immune cell

T-reg: 2.2 nTPM
memory CD4 T-cell: 2 nTPM
gdT-cell: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM
NK-cell: 1.9 nTPM
memory CD8 T-cell: 1.7 nTPM

Brain region

pons: 43 nTPM
cerebral cortex: 43 nTPM
midbrain: 41 nTPM
hypothalamus: 40 nTPM
thalamus: 37 nTPM
medulla oblongata: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
ATM interactor
ASCIZ, forth C2H2 zinc finger domain
ASCIZ, third C2HC zinc finger domain
ASCIZ, first and second C2H2 zinc finger domains
ASCIZ first and second C2H2 zinc finger domains
ASCIZ third C2HC zinc finger domain
ASCIZ forth C2H2 zinc finger domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATMIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATMIN as an antibody target. Whether an autoantibody or antibody against ATMIN could matter depends on whether native ATMIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATMIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATMIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...