Seroatlas · Human Serome Atlas

ARB2A

Cotranscriptional regulator ARB2A

Also known as: ARB2A_HUMAN, C5orf21, DKFZP564D172, FAM172A, Toupee

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUF8
Gene
ARB2A
Ensembl
ENSG00000113391
Chromosome
5
Canonical length
416 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to contribute to siRNA binding activity. Predicted to be involved in neural crest cell development; regulation of alternative mRNA splicing, via spliceosome; and regulatory ncRNA-mediated heterochromatin formation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q8WUF8|ARB2A
     1  MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL
    61  EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK
   121  KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ
   181  IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR
   241  RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV
   301  ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM
   361  LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARB2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 15 nTPM
  • ovary: 14 nTPM
  • retina: 14 nTPM
  • seminal vesicle: 14 nTPM
  • cerebellum: 13 nTPM
  • adipose tissue: 13 nTPM

Single-cell type

  • neutrophils: 1,726 nCPM
  • neutrophil progenitors: 651 nCPM
  • thyrotrophs: 441 nCPM
  • lactotrophs: 438 nCPM
  • somatotrophs: 432 nCPM
  • fibro-adipogenic progenitors: 431 nCPM

Immune cell

  • basophil: 13 nTPM
  • NK-cell: 9.8 nTPM
  • neutrophil: 9.3 nTPM
  • MAIT T-cell: 8.4 nTPM
  • gdT-cell: 8.3 nTPM
  • naive CD8 T-cell: 6.9 nTPM

Brain region

  • cerebellum: 31 nTPM
  • hypothalamus: 28 nTPM
  • spinal cord: 27 nTPM
  • white matter: 27 nTPM
  • medulla oblongata: 27 nTPM
  • basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARB2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARB2A as an antibody target. Whether an autoantibody or antibody against ARB2A could matter depends on whether native ARB2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARB2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARB2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARB2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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