Seroatlas · Human Serome Atlas

CCSER1

Serine-rich coiled-coil domain-containing protein 1

Also known as: CCSE1_HUMAN, FAM190A, KIAA1680

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0I3
Gene: CCSER1
Ensembl: ENSG00000184305
Chromosome: 4
Canonical length: 900 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Implicated in cocaine dependence. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

900 residues, UniProt reviewed canonical sequence.

>Q9C0I3|CCSER1
     1  MGDSGSRRST LVSRLPIFRR SINRRHDSLP SSPSSSNTVG VHSSSPSSTN SSSGSTGKRR
    61  SIFRTPSISF HHKKGSEPKQ EPTNQNLSIS NGAQPGHSNM QKLSLEEHIK TRGRHSVGFS
   121  SSRNKKITRS LTEDFEREKE HSTNKNVFIN CLSSGKSEGD DSGFTEDQTR RSVKQSTRKL
   181  LPKSFSSHYK FSKPVLQSQS ISLVQQSEFS LEVTQYQERE PVLVRASPSC SVDVTERAGS
   241  SLQSPLLSAD LTTAQTPSEF LALTEDSVSE MDAFSKSGSM ASHCDNFGHN DSTSQMSLNS
   301  AAVTKTTTEL TGTVPCAIMS PGKYRLEGQC STESNSLPET SAANQKEVLL QIAELPATSV
   361  SHSESNLPAD SEREENIGLQ NGETMLGTNS PRKLGFYEQH KAIAEHVKGI HPISDSKIIP
   421  TSGDHHIFNK TSHGYEANPA KVLASSLSPF REGRFIERRL RSSSEGTAGS SRMILKPKDG
   481  NIEEVNSLRK QRAGSSSSKM NSLDVLNNLG SCELDEDDLM LDLEFLEEQS LHPSVCREDS
   541  YHSVVSCAAV VLTPMEPMIE MKKREEPEFP EPSKQNLSLK LTKDVDQEAR CSHISRMPNS
   601  PSADWPLQGV EENGGIDSLP FRLMLQDCTA VKTLLLKMKR VLQESADMSP ASSTTSLPVS
   661  PLTEEPVPFK DIMKDECSML KLQLKEKDEL ISQLQEELGK VRHLQKAFAS RVDKSTQTEL
   721  LCYDGLNLKR LETVQGGREA TYRNRIVSQN LSTRDRKAIH TPTEDRFRYS AADQTSPYKN
   781  KTCQLPSLCL SNFLKDKELA EVIKHSRGTY ETLTSDVTQN LRATVGQSSL KPTAKTEGLS
   841  TFLEKPKDQV ATARQHSTFT GRFGQPPRGP ISLHMYSRKN VFLHHNLHST ELQTLGQQDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCSER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

retina: 3.1 nTPM
testis: 2.4 nTPM
adrenal gland: 1.1 nTPM
cerebellum: 0.8 nTPM
cerebral cortex: 0.8 nTPM
heart muscle: 0.8 nTPM

Single-cell type

tuft cells: 4,438 nCPM
adrenal medulla cells: 4,297 nCPM
sertoli cells: 4,099 nCPM
cone photoreceptor cells: 3,834 nCPM
distal convoluted tubule cells: 3,462 nCPM
renal connecting tubule cells: 2,914 nCPM

Immune cell

memory B-cell: 0.2 nTPM
myeloid DC: 0.1 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 16 nTPM
cerebellum: 16 nTPM
hippocampal formation: 15 nTPM
white matter: 14 nTPM
basal ganglia: 14 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Serine-rich coiled-coil domain-containing protein

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of CCSER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCSER1 as an antibody target. Whether an autoantibody or antibody against CCSER1 could matter depends on whether native CCSER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCSER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCSER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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