Seroatlas · Human Serome Atlas

CLINT1

Clathrin interactor 1

Also known as: CLINT, ENTH, EPN4_HUMAN, EPNR, KIAA0171

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14677
Gene: CLINT1
Ensembl: ENSG00000113282
Chromosome: 5
Canonical length: 625 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

625 residues, UniProt reviewed canonical sequence.

>Q14677|CLINT1
     1  MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA TFMYEQFPEL
    61  MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS AREHIYDLRS LENYHFVDEH
   121  GKDQGINIRQ KVKELVEFAQ DDDRLREERK KAKKNKDKYV GVSSDSVGGF RYSERYDPEP
   181  KSKWDEEWDK NKSAFPFSDK LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA
   241  RRGRSPKGEF KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP
   301  DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF GSAAASGSFP
   361  SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA VELVSGSQSA LGPPPAASNS
   421  SDLFDLMGSS QATMTSSQSM NFSMMSTNTV GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP
   481  SVNISLDNLL PGMQPSKPQQ PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ
   541  TNALIGGPMP MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM
   601  PNIAMTSGTV QPKQDAFANF ANFSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLINT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 107 nTPM
bone marrow: 96 nTPM
liver: 84 nTPM
tonsil: 69 nTPM
esophagus: 68 nTPM
kidney: 66 nTPM

Single-cell type

neutrophil progenitors: 612 nCPM
esophageal apical cells: 529 nCPM
salivary duct cells: 507 nCPM
conjunctival goblet cells: 472 nCPM
ocular epithelial cells: 455 nCPM
urothelial cells: 442 nCPM

Immune cell

basophil: 752 nTPM
eosinophil: 180 nTPM
MAIT T-cell: 75 nTPM
T-reg: 66 nTPM
myeloid DC: 63 nTPM
NK-cell: 59 nTPM

Brain region

choroid plexus: 36 nTPM
cerebral cortex: 29 nTPM
hypothalamus: 25 nTPM
thalamus: 25 nTPM
midbrain: 24 nTPM
basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.54
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLINT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLINT1 as an antibody target. Whether an autoantibody or antibody against CLINT1 could matter depends on whether native CLINT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLINT1 is annotated at the cell surface, where native CLINT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLINT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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