Seroatlas · Human Serome Atlas

TXNDC17

Thioredoxin domain-containing protein 17

Also known as: MGC14353, TRP14, TXD17_HUMAN, TXNL5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRA2
Gene: TXNDC17
Ensembl: ENSG00000129235
Chromosome: 17
Canonical length: 123 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables peroxidase activity and protein-disulfide reductase [NAD(P)H] activity. Involved in tumor necrosis factor-mediated signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q9BRA2|TXNDC17
     1  MARYEEVSVS GFEEFHRAVE QHNGKTIFAY FTGSKDAGGK SWCPDCVQAE PVVREGLKHI
    61  SEGCVFIYCQ VGEKPYWKDP NNDFRKNLKV TAVPTLLKYG TPQKLVESEC LQANLVEMLF
   121  SED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

esophagus: 178 nTPM
liver: 68 nTPM
urinary bladder: 64 nTPM
kidney: 63 nTPM
vagina: 58 nTPM
cervix: 54 nTPM

Single-cell type

esophageal apical cells: 3,677 nCPM
esophageal suprabasal cells: 1,800 nCPM
esophageal basal cells: 1,239 nCPM
parietal cells: 859 nCPM
gastric progenitor cells: 567 nCPM
urothelial cells: 535 nCPM

Immune cell

neutrophil: 182 nTPM
non-classical monocyte: 122 nTPM
intermediate monocyte: 118 nTPM
myeloid DC: 116 nTPM
plasmacytoid DC: 110 nTPM
classical monocyte: 105 nTPM

Brain region

choroid plexus: 12 nTPM
white matter: 12 nTPM
hypothalamus: 12 nTPM
spinal cord: 11 nTPM
hippocampal formation: 11 nTPM
cerebellum: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.04
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tumor necrosis factor-mediated signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Thioredoxin-like superfamily
Thioredoxin domain-containing protein 17-like domain
Thioredoxin domain-containing protein 17-like
Thioredoxin domain-containing protein 17-like, thioredoxin domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXNDC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRXR1
DYNLL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC17 as an antibody target. Whether an autoantibody or antibody against TXNDC17 could matter depends on whether native TXNDC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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