Seroatlas · Human Serome Atlas

HMMR

Hyaluronan mediated motility receptor

Also known as: CD168, HMMR_HUMAN, RHAMM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75330
Gene: HMMR
Ensembl: ENSG00000072571
Chromosome: 5
Canonical length: 724 aa
Protein class: CD markers, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins
Subcellular location: Microtubules,Centrosome,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>O75330|HMMR
     1  MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT
    61  TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN
   121  AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK
   181  MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI
   241  SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
   301  EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL
   361  CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL
   421  KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL
   481  QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL
   541  QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
   601  EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC
   661  QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ
   721  ESWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMMR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
thymus: 25 nTPM
bone marrow: 19 nTPM
lymph node: 17 nTPM
tonsil: 17 nTPM
appendix: 9.5 nTPM

Single-cell type

late primary spermatocytes: 171 nCPM
monocyte progenitors: 156 nCPM
erythrocyte progenitors: 128 nCPM
megakaryocyte progenitors: 116 nCPM
late spermatids: 97 nCPM
early spermatids: 72 nCPM

Immune cell

T-reg: 1.5 nTPM
plasmacytoid DC: 0.6 nTPM
NK-cell: 0.5 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

thalamus: 1.7 nTPM
medulla oblongata: 1.2 nTPM
white matter: 1.2 nTPM
pons: 1.1 nTPM
cerebral cortex: 1 nTPM
basal ganglia: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HMMR.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ovarian cancer

Disease | ImmuneIEDB

Conditions an epitope on HMMR was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Hyaluronan-mediated motility receptor, C-terminal
Hyaluronan mediated motility receptor C-terminal
Intracellular hyaluronic acid binding protein
Hyaluronan mediated motility receptor N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMMR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMMR as an antibody target. Whether an autoantibody or antibody against HMMR could matter depends on whether native HMMR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMMR is annotated at the cell surface, where native HMMR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HMMR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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