Seroatlas · Human Serome Atlas

AGGF1

Angiogenic factor with G patch and FHA domains 1

Also known as: AGGF1_HUMAN, FLJ10283, GPATC7, GPATCH7, HSU84971, VG5Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N302
Gene
AGGF1
Ensembl
ENSG00000164252
Chromosome
5
Canonical length
714 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

714 residues, UniProt reviewed canonical sequence.

>Q8N302|AGGF1
     1  MASEAPSPPR SPPPPTSPEP ELAQLRRKVE KLERELRSCK RQVREIEKLL HHTERLYQNA
    61  ESNNQELRTQ VEELSKILQR GRNEDNKKSD VEVQTENHAP WSISDYFYQT YYNDVSLPNK
   121  VTELSDQQDQ AIETSILNSK DHLQVENDAY PGTDRTENVK YRQVDHFASN SQEPASALAT
   181  EDTSLEGSSL AESLRAAAEA AVSQTGFSYD ENTGLYFDHS TGFYYDSENQ LYYDPSTGIY
   241  YYCDVESGRY QFHSRVDLQP YPTSSTKQSK DKKLKKKRKD PDSSATNEEK DLNSEDQKAF
   301  SVEHTSCNEE ENFANMKKKA KIGIHHKNSP PKVTVPTSGN TIESPLHENI SNSTSFKDEK
   361  IMETDSEPEE GEITDSQTED SYDEAITSEG NVTAEDSEDE DEDKIWPPCI RVIVIRSPVL
   421  QIGSLFIITA VNPATIGREK DMEHTLRIPE VGVSKFHAEI YFDHDLQSYV LVDQGSQNGT
   481  IVNGKQILQP KTKCDPYVLE HGDEVKIGET VLSFHIHPGS DTCDGCEPGQ VRAHLRLDKK
   541  DESFVGPTLS KEEKELERRK ELKKIRVKYG LQNTEYEDEK TLKNPKYKDR AGKRREQVGS
   601  EGTFQRDDAP ASVHSEITDS NKGRKMLEKM GWKKGEGLGK DGGGMKTPIQ LQLRRTHAGL
   661  GTGKPSSFED VHLLQNKNKK NWDKARERFT ENFPETKPQK DDPGTMPWVK GTLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGGF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • retina: 21 nTPM
  • epididymis: 20 nTPM
  • testis: 15 nTPM
  • parathyroid gland: 15 nTPM
  • thymus: 13 nTPM
  • duodenum: 13 nTPM

Single-cell type

  • oocytes: 9.2 nCPM
  • monocyte progenitors: 5.7 nCPM
  • kupffer cells: 5.1 nCPM
  • erythrocyte progenitors: 4.9 nCPM
  • late primary spermatocytes: 4.8 nCPM
  • cardiomyocytes: 4.7 nCPM

Immune cell

  • eosinophil: 29 nTPM
  • basophil: 18 nTPM
  • naive CD4 T-cell: 16 nTPM
  • T-reg: 16 nTPM
  • NK-cell: 15 nTPM
  • gdT-cell: 15 nTPM

Brain region

  • white matter: 26 nTPM
  • thalamus: 25 nTPM
  • midbrain: 25 nTPM
  • medulla oblongata: 24 nTPM
  • pons: 24 nTPM
  • hypothalamus: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGGF1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Non-syndromic syndactyly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGGF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGGF1 as an antibody target. Whether an autoantibody or antibody against AGGF1 could matter depends on whether native AGGF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGGF1 is annotated as secreted, so native AGGF1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AGGF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGGF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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