Seroatlas · Human Serome Atlas

RWDD1

RWD domain-containing protein 1

Also known as: PTD013, RWDD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H446
Gene: RWDD1
Ensembl: ENSG00000111832
Chromosome: 6
Canonical length: 243 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cytoplasmic translation and positive regulation of androgen receptor activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q9H446|RWDD1
     1  MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY
    61  PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT
   121  RREEEKKQKE KEAEEAEKQL FHGTPVTIEN FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK
   181  LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD
   241  SAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RWDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 121 nTPM
tongue: 90 nTPM
blood vessel: 72 nTPM
pancreas: 67 nTPM
spinal cord: 66 nTPM
colon: 64 nTPM

Single-cell type

esophageal suprabasal cells: 364 nCPM
parietal cells: 329 nCPM
esophageal basal cells: 322 nCPM
decidual stromal cells: 310 nCPM
esophageal apical cells: 298 nCPM
gastric chief cells: 271 nCPM

Immune cell

T-reg: 118 nTPM
NK-cell: 89 nTPM
memory CD4 T-cell: 86 nTPM
MAIT T-cell: 83 nTPM
naive CD8 T-cell: 79 nTPM
naive CD4 T-cell: 78 nTPM

Brain region

white matter: 60 nTPM
spinal cord: 57 nTPM
cerebellum: 56 nTPM
hypothalamus: 55 nTPM
basal ganglia: 51 nTPM
medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.91
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RWDD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RWDD1 as an antibody target. Whether an autoantibody or antibody against RWDD1 could matter depends on whether native RWDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RWDD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RWDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...