Seroatlas · Human Serome Atlas

NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

Also known as: AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, NTM1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV86
Gene
NTMT1
Ensembl
ENSG00000148335
Chromosome
9
Canonical length
223 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9BV86|NTMT1
     1  MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ RFLREGPNKT
    61  GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA KTYLGEEGKR VRNYFCCGLQ
   121  DFTPEPDSYD VIWIQWVIGH LTDQHLAEFL RRCKGSLRPN GIIVIKDNMA QEGVILDDVD
   181  SSVCRDLDVV RRIICSAGLS LLAEERQENL PDEIYHVYSF ALR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 95 nTPM
  • testis: 90 nTPM
  • tongue: 79 nTPM
  • adrenal gland: 66 nTPM
  • heart muscle: 65 nTPM
  • choroid plexus: 47 nTPM

Single-cell type

  • late spermatids: 1,077 nCPM
  • early spermatids: 417 nCPM
  • late primary spermatocytes: 362 nCPM
  • syncytiotrophoblasts: 159 nCPM
  • migrating cytotrophoblasts: 109 nCPM
  • epididymal efferent duct absorptive cells: 94 nCPM

Immune cell

  • non-classical monocyte: 71 nTPM
  • intermediate monocyte: 55 nTPM
  • plasmacytoid DC: 53 nTPM
  • naive B-cell: 51 nTPM
  • classical monocyte: 50 nTPM
  • myeloid DC: 49 nTPM

Brain region

  • midbrain: 28 nTPM
  • cerebellum: 27 nTPM
  • white matter: 27 nTPM
  • hypothalamus: 26 nTPM
  • thalamus: 26 nTPM
  • medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0.05
gnomAD missense Z
1.29
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTMT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTMT1 as an antibody target. Whether an autoantibody or antibody against NTMT1 could matter depends on whether native NTMT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTMT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NTMT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTMT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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