Seroatlas · Human Serome Atlas

JMJD7

Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

Also known as: JMJD7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C870
Gene
JMJD7
Ensembl
ENSG00000243789
Chromosome
15
Canonical length
316 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>P0C870|JMJD7
     1  MAEAALEAVR SELREFPAAA RELCVPLAVP YLDKPPTPLH FYRDWVCPNR PCIIRNALQH
    61  WPALQKWSLP YFRATVGSTE VSVAVTPDGY ADAVRGDRFM MPAERRLPLS FVLDVLEGRA
   121  QHPGVLYVQK QCSNLPSELP QLLPDLESHV PWASEALGKM PDAVNFWLGE AAAVTSLHKD
   181  HYENLYCVVS GEKHFLFHPP SDRPFIPYEL YTPATYQLTE EGTFKVVDEE AMEKVPWIPL
   241  DPLAPDLARY PSYSQAQALR CTVRAGEMLY LPALWFHHVQ QSQGCIAVNF WYDMEYDLKY
   301  SYFQLLDSLT KASGLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JMJD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 33 nTPM
  • skin: 31 nTPM
  • cerebellum: 29 nTPM
  • salivary gland: 21 nTPM
  • spinal cord: 20 nTPM
  • choroid plexus: 19 nTPM

Single-cell type

  • brain excitatory neurons: 5.8 nCPM
  • other brain neurons: 5 nCPM
  • choroid plexus epithelial cells: 4.5 nCPM
  • microglia: 4 nCPM
  • oligodendrocyte progenitor cells: 3.8 nCPM
  • brain inhibitory neurons: 3.6 nCPM

Immune cell

  • naive CD4 T-cell: 20 nTPM
  • memory CD8 T-cell: 19 nTPM
  • T-reg: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • non-classical monocyte: 16 nTPM
  • memory CD4 T-cell: 16 nTPM

Brain region

  • cerebellum: 47 nTPM
  • choroid plexus: 22 nTPM
  • cerebral cortex: 20 nTPM
  • pons: 20 nTPM
  • white matter: 19 nTPM
  • basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
-0.92
DepMap mean gene effect
-0.03
DepMap dependency class
none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JMJD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JMJD7 as an antibody target. Whether an autoantibody or antibody against JMJD7 could matter depends on whether native JMJD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JMJD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JMJD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JMJD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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