Seroatlas · Human Serome Atlas

ZC3H15

Zinc finger CCCH domain-containing protein 15

Also known as: LEREPO4, ZC3HF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WU90
Gene: ZC3H15
Ensembl: ENSG00000065548
Chromosome: 2
Canonical length: 426 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q8WU90|ZC3H15
     1  MPPKKQAQAG GSKKAEQKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTHQV KFGQQNPRQV
    61  AQSEAEKKLK KDDKKKELQE LNELFKPVVA AQKISKGADP KSVVCAFFKQ GQCTKGDKCK
   121  FSHDLTLERK CEKRSVYIDA RDEELEKDTM DNWDEKKLEE VVNKKHGEAE KKKPKTQIVC
   181  KHFLEAIENN KYGWFWVCPG GGDICMYRHA LPPGFVLKKD KKKEEKEDEI SLEDLIERER
   241  SALGPNVTKI TLESFLAWKK RKRQEKIDKL EQDMERRKAD FKAGKALVIS GREVFEFRPE
   301  LVNDDDEEAD DTRYTQGTGG DEVDDSVSVN DIDLSLYIPR DVDETGITVA SLERFSTYTS
   361  DKDENKLSEA SGGRAENGER SDLEEDNERE GTENGAIDAV PVDENLFTGE DLDELEEELN
   421  TLDLEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 122 nTPM
liver: 63 nTPM
skeletal muscle: 51 nTPM
urinary bladder: 51 nTPM
lymph node: 50 nTPM
kidney: 50 nTPM

Single-cell type

late spermatids: 502 nCPM
oocytes: 415 nCPM
esophageal apical cells: 297 nCPM
esophageal suprabasal cells: 297 nCPM
gastric progenitor cells: 296 nCPM
esophageal basal cells: 258 nCPM

Immune cell

non-classical monocyte: 75 nTPM
T-reg: 67 nTPM
intermediate monocyte: 62 nTPM
NK-cell: 61 nTPM
basophil: 60 nTPM
memory CD8 T-cell: 57 nTPM

Brain region

cerebral cortex: 51 nTPM
hypothalamus: 49 nTPM
cerebellum: 46 nTPM
hippocampal formation: 44 nTPM
medulla oblongata: 44 nTPM
pons: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.9
gnomAD missense Z: 1.83
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H15 as an antibody target. Whether an autoantibody or antibody against ZC3H15 could matter depends on whether native ZC3H15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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