LRRC4B

Protein identityUniProt · HPA

UniProt accession

Q9NT99

Gene

LRRC4B

Ensembl

ENSG00000131409

Chromosome

19

Canonical length

713 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

713 residues, UniProt reviewed canonical sequence.

>Q9NT99|LRRC4B
     1  MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG SPPATSCPVA
    61  CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV IRTDTFKHLR HLEILQLSKN
   121  LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP TQAFEYLSKL RELWLRNNPI ESIPSYAFNR
   181  VPSLRRLDLG ELKRLEYISE AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR
   241  LDLIRPGSFQ GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL
   301  HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY IGELDQSHFT
   361  CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN GTLMTHGSYR VRISVLHDGT
   421  LNFTNVTVQD TGQYTCMVTN SAGNTTASAT LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG
   481  SGGYTYFTTV TVETLETQPG EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA
   541  PAPRSSRPTE KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR
   601  KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL ALPALERDHL
   661  NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF KSGSKENVQE TQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

100 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.4

gnomAD pLI

0.88

gnomAD missense Z

4.36

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of synapse assembly
• regulation of postsynaptic density assembly
• regulation of presynapse assembly
• synaptic membrane adhesion

Molecular functions

• cell-cell adhesion mediator activity
• signaling receptor binding

Cellular components

• cerebellar mossy fiber
• glutamatergic synapse
• plasma membrane
• postsynaptic density membrane
• presynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Immunoglobulin-like domain superfamily
• Leucine-rich repeat and transmembrane domain-containing protein
• Leucine Rich Repeat
• Immunoglobulin I-set domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Cell projection
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Repeat
• Signal
• Synapse
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LRRC4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG4
• PTPRF