Seroatlas · Human Serome Atlas

GPR85

Probable G-protein coupled receptor 85

Also known as: GPR85_HUMAN, SREB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60893
Gene
GPR85
Ensembl
ENSG00000164604
Chromosome
7
Canonical length
370 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>P60893|GPR85
     1  MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL
    61  DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY
   121  LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR
   181  ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA
   241  ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
   301  YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS
   361  RLPREPYCVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 30 nTPM
  • basal ganglia: 19 nTPM
  • hippocampal formation: 16 nTPM
  • midbrain: 14 nTPM
  • hypothalamus: 12 nTPM
  • cerebral cortex: 12 nTPM

Single-cell type

  • late primary spermatocytes: 201 nCPM
  • early spermatids: 187 nCPM
  • hofbauer cells: 88 nCPM
  • retinal horizontal cells: 74 nCPM
  • retinal amacrine cells: 62 nCPM
  • retinal bipolar cells: 60 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • intermediate monocyte: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM

Brain region

  • hippocampal formation: 36 nTPM
  • cerebral cortex: 33 nTPM
  • white matter: 31 nTPM
  • amygdala: 30 nTPM
  • pons: 29 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.77
gnomAD missense Z
2.05
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR85 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR85 as an antibody target. Whether an autoantibody or antibody against GPR85 could matter depends on whether native GPR85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR85 is annotated at the cell surface, where native GPR85 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR85. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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