LRFN2

Protein identityUniProt · HPA

UniProt accession

Q9ULH4

Gene

LRFN2

Ensembl

ENSG00000156564

Chromosome

6

Canonical length

789 aa

Protein class

Predicted membrane proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Predicted to be involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cell surface; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

789 residues, UniProt reviewed canonical sequence.

>Q9ULH4|LRFN2
     1  METLLGGLLA FGMAFAVVDA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI DRRTVELRLG
    61  GNFIIHISRQ DFANMTGLVD LTLSRNTISH IQPFSFLDLE SLRSLHLDSN RLPSLGEDTL
   121  RGLVNLQHLI VNNNQLGGIA DEAFEDFLLT LEDLDLSYNN LHGLPWDSVR RMVNLHQLSL
   181  DHNLLDHIAE GTFADLQKLA RLDLTSNRLQ KLPPDPIFAR SQASALTATP FAPPLSFSFG
   241  GNPLHCNCEL LWLRRLERDD DLETCGSPGG LKGRYFWHVR EEEFVCEPPL ITQHTHKLLV
   301  LEGQAATLKC KAIGDPSPLI HWVAPDDRLV GNSSRTAVYD NGTLDIFITT SQDSGAFTCI
   361  AANAAGEATA MVEVSIVQLP HLSNSTSRTA PPKSRLSDIT GSSKTSRGGG GSGGGEPPKS
   421  PPERAVLVSE VTTTSALVKW SVSKSAPRVK MYQLQYNCSD DEVLIYRMIP ASNKAFVVNN
   481  LVSGTGYDLC VLAMWDDTAT TLTATNIVGC AQFFTKADYP QCQSMHSQIL GGTMILVIGG
   541  IIVATLLVFI VILMVRYKVC NHEAPSKMAA AVSNVYSQTN GAQPPPPSSA PAGAPPQGPP
   601  KVVVRNELLD FTASLARASD SSSSSSLGSG EAAGLGRAPW RIPPSAPRPK PSLDRLMGAF
   661  ASLDLKSQRK EELLDSRTPA GRGAGTSARG HHSDREPLLG PPAARARSLL PLPLEGKAKR
   721  SHSFDMGDFA AAAAGGVVPG GYSPPRKVSN IWTKRSLSVN GMLLPFEESD LVGARGTFGS
   781  SEWVMESTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRFN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

6.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.71

gnomAD pLI

0.01

gnomAD missense Z

1.6

DepMap mean gene effect

0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• modulation of chemical synaptic transmission
• regulation of postsynapse organization

Cellular components

• cell surface
• plasma membrane
• postsynaptic density membrane
• presynapse
• Schaffer collateral - CA1 synapse

Protein domainsUniProt · Pfam · InterPro

• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Fibronectin type III
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Fibronectin type III superfamily
• Immunoglobulin-like domain superfamily
• Leucine-rich repeat and fibronectin type-III domain-containing
• Fibronectin type III domain
• Immunoglobulin I-set domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Leucine-rich repeat
• Membrane
• Postsynaptic cell membrane
• Repeat
• Signal
• Synapse
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LRFN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG1
• DLG2
• DLG3
• DLG4
• GRIN2A
• GRIN1