Seroatlas · Human Serome Atlas

ZDHHC5

Palmitoyltransferase ZDHHC5

Also known as: DHHC5, KIAA1748, ZDHC5_HUMAN, ZNF375

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0B5
Gene
ZDHHC5
Ensembl
ENSG00000156599
Chromosome
11
Canonical length
715 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of defense response; positive regulation of protein localization to plasma membrane; and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in nucleoplasm; phagocytic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q9C0B5|ZDHHC5
     1  MPAESGKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LYVSPAVPIY NAIMFLFVLA
    61  NFSMATFMDP GIFPRAEEDE DKEDDFRAPL YKTVEIKGIQ VRMKWCATCR FYRPPRCSHC
   121  SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF LFLLSLTAHI MGVFGFGLLY VLYHIEELSG
   181  VRTAVTMAVM CVAGLFFIPV AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV
   241  SRVLCSSPAP RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRTKSKGSL
   301  EITESQSADA EPPPPPKPDL SRYTGLRTHL GLATNEDSSL LAKDSPPTPT MYKYRPGYSS
   361  SSTSAAMPHS SSAKLSRGDS LKEPTSIAES SRHPSYRSEP SLEPESFRSP TFGKSFHFDP
   421  LSSGSRSSSL KSAQGTGFEL GQLQSIRSEG TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP
   481  DFESVQAGPE PDPPLGYTSP FLSARLAQQR EAERHPRLVP TGPTHREPSP VRYDNLSRHI
   541  VASLQEREKL LRQSPPLPGR EEEPGLGDSG IQSTPGSGHA PRTSSSSDDS KRSPLGKTPL
   601  GRPAVPRFGK PDGLRGRGVG SPEPGPTAPY LGRSMSYSSQ KAQPGVSETE EVALQPLLTP
   661  KDEVQLKTTY SKSNGQPKSL GSASPGPGQP PLSSPTRGGV KKVSGVGGTT YEISV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 57 nTPM
  • skin: 43 nTPM
  • parathyroid gland: 43 nTPM
  • tongue: 43 nTPM
  • urinary bladder: 40 nTPM
  • skeletal muscle: 38 nTPM

Single-cell type

  • esophageal apical cells: 156 nCPM
  • ocular epithelial cells: 105 nCPM
  • rod photoreceptor cells: 89 nCPM
  • esophageal suprabasal cells: 83 nCPM
  • urothelial cells: 78 nCPM
  • cone photoreceptor cells: 64 nCPM

Immune cell

  • basophil: 12 nTPM
  • plasmacytoid DC: 9 nTPM
  • MAIT T-cell: 8.3 nTPM
  • non-classical monocyte: 8.2 nTPM
  • eosinophil: 7.1 nTPM
  • T-reg: 7 nTPM

Brain region

  • choroid plexus: 32 nTPM
  • thalamus: 32 nTPM
  • hypothalamus: 28 nTPM
  • midbrain: 28 nTPM
  • medulla oblongata: 27 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
1.85
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC5 as an antibody target. Whether an autoantibody or antibody against ZDHHC5 could matter depends on whether native ZDHHC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC5 is annotated at the cell surface, where native ZDHHC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZDHHC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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