Guanylate kinase/L-type calcium channel beta subunit
IPR008145
Definition
This entry represents a domain found in guanylate kinase ([ec:2.7.4.8]) and in L-type calcium channel. Guanylate kinase ([ec:2.7.4.8]) (GK) PMID:1314905 catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [[cite:PMID:1310897], [cite:PMID:8097461], [cite:PMID:1329277]] to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel, since they form the drug binding domain. Other properties, such as gating voltage-dependence, G protein modulation and kinase susceptibility, are influenced by alpha-2, delta and beta subunits.
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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