CXADR
Coxsackievirus and adenovirus receptor
Also known as: CAR, CXAR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P78310
- Gene
- CXADR
- Ensembl
- ENSG00000154639
- Chromosome
- 21
- Canonical length
- 365 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins, Transporters
- Subcellular location
- Nucleoplasm,Plasma membrane,Cell Junctions
- Secretome location
- Secreted - unknown location
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Canonical amino-acid sequenceUniProt
365 residues, UniProt reviewed canonical sequence.
>P78310|CXADR
1 MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS
61 PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC
121 KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD
181 SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA
241 GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS
301 SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK
361 DGSIVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CXADR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- skin: 50 nTPM
- liver: 46 nTPM
- small intestine: 40 nTPM
- duodenum: 40 nTPM
- stomach: 29 nTPM
- rectum: 24 nTPM
Single-cell type
- urothelial cells: 716 nCPM
- enterocytes: 531 nCPM
- endometrial luminal cells: 394 nCPM
- colonocytes: 333 nCPM
- basal keratinocytes: 328 nCPM
- suprabasal keratinocytes: 301 nCPM
Immune cell
- basophil: 0.9 nTPM
- memory CD4 T-cell: 0.6 nTPM
- naive CD4 T-cell: 0.6 nTPM
- MAIT T-cell: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
Brain region
- choroid plexus: 57 nTPM
- white matter: 45 nTPM
- medulla oblongata: 32 nTPM
- spinal cord: 29 nTPM
- cerebral cortex: 28 nTPM
- hippocampal formation: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.37
- gnomAD missense Z
- 0.98
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- actin cytoskeleton organization
- AV node cell to bundle of His cell communication
- cardiac muscle cell development
- cell-cell junction organization
- defense response to virus
- epithelial structure maintenance
- gamma-delta T cell activation
- germ cell migration
- heart development
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
- homotypic cell-cell adhesion
- mitochondrion organization
- neutrophil chemotaxis
- regulation of AV node cell action potential
- transepithelial transport
- AV node cell-bundle of His cell adhesion involved in cell communication
Molecular functions
- beta-catenin binding
- cell adhesion molecule binding
- connexin binding
- identical protein binding
- integrin binding
- PDZ domain binding
- signaling receptor binding
- virus receptor activity
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication
Cellular components
- acrosomal vesicle
- adherens junction
- apicolateral plasma membrane
- basolateral plasma membrane
- bicellular tight junction
- cell body
- cell junction
- cell-cell junction
- cytoplasm
- extracellular region
- extracellular space
- filopodium
- growth cone
- intercalated disc
- membrane raft
- neuromuscular junction
- neuron projection
- nucleoplasm
- plasma membrane
- protein-containing complex
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CXADR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CXADR as an antibody target. Whether an autoantibody or antibody against CXADR could matter depends on whether native CXADR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CXADR is annotated at the cell surface, where native CXADR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CXADR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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