Synaptic Scaffolding LAP/MAGUK Families
IPR050614
Definition
The LAP (LRR and PDZ) and MAGUK protein families are involved in synaptic function and cellular signaling. Members of these families are essential for synaptic plasticity, synaptogenesis, and maintaining synaptic architecture. They serve as scaffolding proteins, clustering crucial synaptic proteins at postsynaptic densities and regulating the surface expression of receptors like NMDA and AMPA. Some family members are involved in cell polarity, proliferation, migration, and apoptosis, playing roles in epithelial and neuronal morphogenesis, T-cell polarization, and pain perception. They may also influence signal transduction pathways, including Wnt and Rho, and modulate the trafficking of channels and receptors within cells.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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