LRFN4

Protein identityUniProt · HPA

UniProt accession

Q6PJG9

Gene

LRFN4

Ensembl

ENSG00000173621

Chromosome

11

Canonical length

635 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>Q6PJG9|LRFN4
     1  MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT VELRLADNFI
    61  QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS LHLDGNRLVE LGTGSLRGPV
   121  NLQHLILSGN QLGRIAPGAF DDFLESLEDL DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL
   181  IDALPPGAFA QLGQLSRLDL TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC
   241  ELLWLRRLAR PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL
   301  RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT CIATNPAGEA
   361  TARVELRVLA LPHGGNSSAE GGRPGPSDIA ASARTAAEGE GTLESEPAVQ VTEVTATSGL
   421  VSWGPGRPAD PVWMFQIQYN SSEDETLIYR IVPASSHHFL LKHLVPGADY DLCLLALSPA
   481  AGPSDLTATR LLGCAHFSTL PASPLCHALQ AHVLGGTLTV AVGGVLVAAL LVFTVALLVR
   541  GRGAGNGRLP LKLSHVQSQT NGGPSPTPKA HPPRSPPPRP QRSCSLDLGD AGCYGYARRL
   601  GGAWARRSHS VHGGLLGAGC RGVGGSAERL EESVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRFN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

35 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.39

gnomAD pLI

0.91

gnomAD missense Z

1.25

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of postsynaptic density assembly
• regulation of presynapse assembly
• synaptic membrane adhesion

Cellular components

• cell surface
• GABA-ergic synapse
• glutamatergic synapse
• plasma membrane
• postsynaptic density membrane

Protein domainsUniProt · Pfam · InterPro

• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Fibronectin type III
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Fibronectin type III superfamily
• Immunoglobulin-like domain superfamily
• Leucine-rich repeat and fibronectin type-III domain-containing
• Fibronectin type III domain
• Leucine Rich Repeat
• Immunoglobulin I-set domain
• Leucine rich repeat

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LRFN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG1
• DLG2
• DLG3
• DLG4