Seroatlas · Human Serome Atlas

FAM81A

Protein FAM81A

Also known as: FA81A_HUMAN, MGC26690

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBF8
Gene: FAM81A
Ensembl: ENSG00000157470
Chromosome: 15
Canonical length: 368 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable molecular condensate scaffold activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q8TBF8|FAM81A
     1  MENMHLRRVR TMPRHSQSLT MAPYSSVSLV EQLEDRILCH EKTTAALVEH AFRIKDDIVN
    61  SLQKMQNKGG GDRLARLFLE EHIRNITAIV KQLNRDIEVL QEQIRARDNI SYGTNSALKT
   121  LEMRQLSGLG DLRGRVARCD ASIARLSAEH KTTYEGLQHL NKEQQAAKLI LETKIKDAEG
   181  QISQLLNRVD LSISEQSTKL KMSHRDSNHQ LQLLDTKFKG TVEELSNQIL SARSWLQQEQ
   241  ERIEKELLQK IDQLSLIVKE NSGASERDME KKLSQMSARL DKIEEGQKKT FDGQRTRQEE
   301  EKMHGRITKL ELQMNQNIKE MKAEVNAGFT AVYESIGSLR QVLEAKMKLD RDQLQKQIQL
   361  MQKPETPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM81A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 26 nTPM
hippocampal formation: 12 nTPM
amygdala: 11 nTPM
basal ganglia: 7.4 nTPM
hypothalamus: 6.9 nTPM
cervix: 6.3 nTPM

Single-cell type

ependymal cells: 180 nCPM
podocytes: 163 nCPM
renal collecting duct principal cells: 160 nCPM
respiratory ciliated cells: 122 nCPM
epididymal basal cells: 97 nCPM
medullary thymic epithelial cells: 67 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
myeloid DC: 5.1 nTPM
naive B-cell: 2.3 nTPM
memory B-cell: 0.9 nTPM
classical monocyte: 0.5 nTPM
neutrophil: 0.3 nTPM

Brain region

cerebral cortex: 52 nTPM
basal ganglia: 38 nTPM
white matter: 33 nTPM
hippocampal formation: 29 nTPM
hypothalamus: 29 nTPM
amygdala: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.19
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

molecular condensate scaffold activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein FAM81

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM81A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM81A as an antibody target. Whether an autoantibody or antibody against FAM81A could matter depends on whether native FAM81A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM81A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM81A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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