Seroatlas · Human Serome Atlas

LRFN1

Leucine-rich repeat and fibronectin type III domain-containing protein 1

Also known as: KIAA1484, LRFN1_HUMAN, SALM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P244
Gene
LRFN1
Ensembl
ENSG00000128011
Chromosome
19
Canonical length
771 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in regulation of postsynaptic density assembly. Predicted to be located in plasma membrane. Predicted to be active in postsynaptic density membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

771 residues, UniProt reviewed canonical sequence.

>Q9P244|LRFN1
     1  MAPGPFSSAL LSPPPAALPF LLLLWAGASR GQPCPGRCIC QNVAPTLTML CAKTGLLFVP
    61  PAIDRRVVEL RLTDNFIAAV RRRDFANMTS LVHLTLSRNT IGQVAAGAFA DLRALRALHL
   121  DSNRLAEVRG DQLRGLGNLR HLILGNNQIR RVESAAFDAF LSTVEDLDLS YNNLEALPWE
   181  AVGQMVNLNT LTLDHNLIDH IAEGTFVQLH KLVRLDMTSN RLHKLPPDGL FLRSQGTGPK
   241  PPTPLTVSFG GNPLHCNCEL LWLRRLTRED DLETCATPEH LTDRYFWSIP EEEFLCEPPL
   301  ITRQAGGRAL VVEGQAVSLR CRAVGDPEPV VHWVAPDGRL LGNSSRTRVR GDGTLDVTIT
   361  TLRDSGTFTC IASNAAGEAT APVEVCVVPL PLMAPPPAAP PPLTEPGSSD IATPGRPGAN
   421  DSAAERRLVA AELTSNSVLI RWPAQRPVPG IRMYQVQYNS SVDDSLVYRM IPSTSQTFLV
   481  NDLAAGRAYD LCVLAVYDDG ATALPATRVV GCVQFTTAGD PAPCRPLRAH FLGGTMIIAI
   541  GGVIVASVLV FIVLLMIRYK VYGDGDSRRV KGSRSLPRVS HVCSQTNGAG TGAAQAPALP
   601  AQDHYEALRE VESQAAPAVA VEAKAMEAET ASAEPEVVLG RSLGGSATSL CLLPSEETSG
   661  EESRAAVGPR RSRSGALEPP TSAPPTLALV PGGAAARPRP QQRYSFDGDY GALFQSHSYP
   721  RRARRTKRHR STPHLDGAGG GAAGEDGDLG LGSARACLAF TSTEWMLEST V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRFN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 14 nTPM
  • cerebral cortex: 12 nTPM
  • hypothalamus: 9.5 nTPM
  • amygdala: 8 nTPM
  • hippocampal formation: 7.9 nTPM
  • basal ganglia: 5.2 nTPM

Single-cell type

  • neutrophils: 34 nCPM
  • retinal bipolar cells: 27 nCPM
  • retinal amacrine cells: 11 nCPM
  • other brain neurons: 11 nCPM
  • brain excitatory neurons: 9.7 nCPM
  • brain inhibitory neurons: 7.9 nCPM

Immune cell

  • eosinophil: 0.9 nTPM
  • neutrophil: 0.6 nTPM
  • basophil: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 34 nTPM
  • basal ganglia: 27 nTPM
  • amygdala: 26 nTPM
  • hypothalamus: 25 nTPM
  • hippocampal formation: 24 nTPM
  • cerebellum: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRFN1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • LRFN1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.9
gnomAD missense Z
3.31
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRFN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRFN1 as an antibody target. Whether an autoantibody or antibody against LRFN1 could matter depends on whether native LRFN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRFN1 is annotated at the cell surface, where native LRFN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRFN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRFN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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