Seroatlas · Human Serome Atlas

FGF1

Fibroblast growth factor 1

Also known as: AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGF1_HUMAN, FGFA, GLIO703, HBGF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05230
Gene
FGF1
Ensembl
ENSG00000113578
Chromosome
5
Canonical length
155 aa
Protein class
Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>P05230|FGF1
     1  MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ
    61  LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK
   121  NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
282 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 282 nTPM
  • spinal cord: 255 nTPM
  • hippocampal formation: 183 nTPM
  • basal ganglia: 182 nTPM
  • amygdala: 175 nTPM
  • hypothalamus: 142 nTPM

Single-cell type

  • podocytes: 2,009 nCPM
  • cone photoreceptor cells: 584 nCPM
  • rod photoreceptor cells: 523 nCPM
  • adipocytes: 202 nCPM
  • retinal bipolar cells: 172 nCPM
  • oligodendrocytes: 141 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • gdT-cell: 0.4 nTPM
  • MAIT T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.2 nTPM

Brain region

  • white matter: 347 nTPM
  • pons: 338 nTPM
  • basal ganglia: 327 nTPM
  • hypothalamus: 308 nTPM
  • medulla oblongata: 297 nTPM
  • thalamus: 296 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.44
gnomAD missense Z
0.46
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF1 as an antibody target. Whether an autoantibody or antibody against FGF1 could matter depends on whether native FGF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF1 is annotated at the cell surface, where native FGF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FGF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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