Seroatlas · Human Serome Atlas

HEXIM2

Protein HEXIM2

Also known as: FLJ32384, HEXI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MH2
Gene: HEXIM2
Ensembl: ENSG00000168517
Chromosome: 17
Canonical length: 286 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>Q96MH2|HEXIM2
     1  MMATPNQTAC NAESPVALEE AKTSGAPGSP QTPPERHDSG GSLPLTPRME SHSEDEDLAG
    61  AVGGLGWNSR SPRTQSPGGC SAEAVLARKK HRRRPSKRKR HWRPYLELSW AEKQQRDERQ
   121  SQRASRVREE MFAKGQPVAP YNTTQFLMND RDPEEPNLDV PHGISHPGSS GESEAGDSDG
   181  RGRAHGEFQR KDFSETYERF HTESLQGRSK QELVRDYLEL EKRLSQAEEE TRRLQQLQAC
   241  TGQQSCRQVE ELAAEVQRLR TENQRLRQEN QMWNREGCRC DEEPGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEXIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 44 nTPM
testis: 32 nTPM
liver: 12 nTPM
tongue: 10 nTPM
kidney: 8.9 nTPM
basal ganglia: 8.7 nTPM

Single-cell type

late spermatids: 426 nCPM
late primary spermatocytes: 169 nCPM
cardiomyocytes: 164 nCPM
early spermatids: 132 nCPM
platelets: 124 nCPM
oocytes: 78 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
total PBMC: 11 nTPM
classical monocyte: 9.4 nTPM
memory B-cell: 8.9 nTPM
myeloid DC: 8.3 nTPM
eosinophil: 8.2 nTPM

Brain region

choroid plexus: 23 nTPM
cerebellum: 19 nTPM
thalamus: 16 nTPM
medulla oblongata: 16 nTPM
amygdala: 16 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.03
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HEXIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEXIM2 as an antibody target. Whether an autoantibody or antibody against HEXIM2 could matter depends on whether native HEXIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEXIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEXIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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