Seroatlas · Human Serome Atlas

CACTIN

Splicing factor Cactin

Also known as: C19orf29, CATIN_HUMAN, fSAPc, NY-REN-24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUQ7
Gene: CACTIN
Ensembl: ENSG00000105298
Chromosome: 19
Canonical length: 758 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>Q8WUQ7|CACTIN
     1  MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR RSRERRSDSE
    61  EERWQRSGMR SRSPPRPKWH SRDGSSQSDS GEEQSRGQWA RRRRRARSWS PSSSASSSAS
   121  PGRSQSPRAA AAALSQQQSL QERLRLREER KQQEELMKAF ETPEEKRARR LAKKEAKERK
   181  KREKMGWGEE YMGYTNTDNP FGDNNLLGTF IWNKALEKKG ISHLEEKELK ERNKRIQEDN
   241  RLELQKVKQL RLEREREKAM REQELEMLQR EKEAEHFKTW EEQEDNFHLQ QAKLRSKIRI
   301  RDGRAKPIDL LAKYISAEDD DLAVEMHEPY TFLNGLTVAD MEDLLEDIQV YMELEQGKNA
   361  DFWRDMTTIT EDEISKLRKL EASGKGPGER REGVNASVSS DVQSVFKGKT YNQLQVIFQG
   421  IEGKIRAGGP NLDMGYWESL LQQLRAHMAR ARLRERHQDV LRQKLYKLKQ EQGVESEPLF
   481  PILKQEPQSP SRSLEPEDAA PTPPGPSSEG GPAEAEVDGA TPTEGDGDGD GEGEGEGEAV
   541  LMEEDLIQQS LDDYDAGRYS PRLLTAHELP LDAHVLEPDE DLQRLQLSRQ QLQVTGDASE
   601  SAEDIFFRRA KEGMGQDEAQ FSVEMPLTGK AYLWADKYRP RKPRFFNRVH TGFEWNKYNQ
   661  THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA DNKDFAILRF HAGPPYEDIA
   721  FKIVNREWEY SHRHGFRCQF ANGIFQLWFH FKRYRYRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACTIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

ovary: 24 nTPM
cerebellum: 22 nTPM
liver: 20 nTPM
skeletal muscle: 19 nTPM
cerebral cortex: 19 nTPM
hippocampal formation: 18 nTPM

Single-cell type

megakaryocytes: 19 nCPM
platelets: 17 nCPM
epididymal clear cells: 14 nCPM
early primary spermatocytes: 12 nCPM
paneth cells: 12 nCPM
differentiating spermatogonia: 11 nCPM

Immune cell

plasmacytoid DC: 1.4 nTPM
gdT-cell: 1.2 nTPM
intermediate monocyte: 1 nTPM
naive CD8 T-cell: 0.8 nTPM
memory B-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM

Brain region

medulla oblongata: 19 nTPM
cerebral cortex: 18 nTPM
amygdala: 17 nTPM
hippocampal formation: 17 nTPM
white matter: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 3.2
DepMap mean gene effect: -0.93
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Splicing factor cactin, central domain
Splicing factor Cactin, C-terminal
Cactus-binding C-terminus of cactin protein
Conserved mid region of cactin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACTIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACTIN as an antibody target. Whether an autoantibody or antibody against CACTIN could matter depends on whether native CACTIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACTIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CACTIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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