Seroatlas · Human Serome Atlas

HEXIM1

Protein HEXIM1

Also known as: CLP-1, EDG1, HEXI1_HUMAN, HIS1, MAQ1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94992
Gene: HEXIM1
Ensembl: ENSG00000186834
Chromosome: 17
Canonical length: 359 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles
Quaternary structure: Homooligomer

OverviewNCBI Gene

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>O94992|HEXIM1
     1  MAEPFLSEYQ HQPQTSNCTG AAAVQEELNP ERPPGAEERV PEEDSRWQSR AFPQLGGRPG
    61  PEGEGSLESQ PPPLQTQACP ESSCLREGEK GQNGDDSSAG GDFPPPAEVE PTPEAELLAQ
   121  PCHDSEASKL GAPAAGGEEE WGQQQRQLGK KKHRRRPSKK KRHWKPYYKL TWEEKKKFDE
   181  KQSLRASRIR AEMFAKGQPV APYNTTQFLM DDHDQEEPDL KTGLYSKRAA AKSDDTSDDD
   241  FMEEGGEEDG GSDGMGGDGS EFLQRDFSET YERYHTESLQ NMSKQELIKE YLELEKCLSR
   301  MEDENNRLRL ESKRLGGDDA RVRELELELD RLRAENLQLL TENELHRQQE RAPLSKFGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEXIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 34 nTPM
skeletal muscle: 31 nTPM
adrenal gland: 31 nTPM
blood vessel: 30 nTPM
liver: 26 nTPM
spleen: 24 nTPM

Single-cell type

syncytiotrophoblasts: 594 nCPM
megakaryocytes: 315 nCPM
epididymal basal cells: 291 nCPM
breast myoepithelial cells: 270 nCPM
tuft cells: 254 nCPM
colonocytes: 212 nCPM

Immune cell

basophil: 16 nTPM
neutrophil: 10 nTPM
non-classical monocyte: 7.3 nTPM
eosinophil: 6.8 nTPM
intermediate monocyte: 6.1 nTPM
gdT-cell: 4.2 nTPM

Brain region

thalamus: 46 nTPM
midbrain: 44 nTPM
spinal cord: 41 nTPM
medulla oblongata: 39 nTPM
choroid plexus: 38 nTPM
hypothalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HEXIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEXIM1 as an antibody target. Whether an autoantibody or antibody against HEXIM1 could matter depends on whether native HEXIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEXIM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEXIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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