Seroatlas · Human Serome Atlas

TTC28

Tetratricopeptide repeat protein 28

Also known as: KIAA1043, TTC28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AY4
Gene: TTC28
Ensembl: ENSG00000100154
Chromosome: 22
Canonical length: 2481 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2481 residues, UniProt reviewed canonical sequence.

>Q96AY4|TTC28
     1  MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG PVLSKAEFVE
    61  KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL
   121  LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE
   181  PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL
   241  SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
   301  LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM
   361  GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV
   421  LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL
   481  GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE
   541  LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
   601  GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD
   661  LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL LSLAQSLNNS QAKFRALGNL
   721  GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR RLEASAYAAL GTAYRMIQKY DKALGYHTQE
   781  LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM
   841  GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY
   901  EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY
   961  GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA CGLGGVYQQM GEYDTALQYH
  1021  QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY
  1081  SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL
  1141  YRASALFETI RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
  1201  ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGIVKF
  1261  HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR EALGVESHYS RACASSETES
  1321  EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS
  1381  LPRRQSSFAK PPLRALYDLL IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS
  1441  SSNEYLYERF GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL
  1501  WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS WKLSALVLTP
  1561  SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP LQELLLTAAD VLDLQLPVKL
  1621  VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFIH AFYSSLLNGL
  1681  KASAALGEAM KVVQSSKAFS HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD
  1741  ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP
  1801  AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS RAVKNMVGML
  1861  HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA ALGFDLCEVG QEEVILKTGK
  1921  QANRRTVHFA LQSLLSLFDS TELPKRLSLD SSSSLESLAS AQSVSNALPL GYQQPPFSPT
  1981  GADSIASDAI SVYSLSSIAS SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ
  2041  LPPQTRPAGN KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK
  2101  GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNPKLDPQ
  2161  ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP SSTAVFRASE TSAFSRPVLS
  2221  HQKSQPSPVT VKPKPPARSS SLPKVSSGYS SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ
  2281  LDQPLFKLKY PSSPYSAHIS KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP
  2341  DIDKLKMAAI DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR
  2401  HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP PATAPARPLR
  2461  LPSGNGYKFL SPGRFFPSSK C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

ovary: 13 nTPM
endometrium: 9.6 nTPM
epididymis: 9.3 nTPM
fallopian tube: 8.7 nTPM
cervix: 8.3 nTPM
placenta: 8.3 nTPM

Single-cell type

fibro-adipogenic progenitors: 908 nCPM
proximal tubule cells: 897 nCPM
pituicytes/fscs: 757 nCPM
mesothelial cells: 743 nCPM
retinal bipolar cells: 653 nCPM
endometrial stromal cells: 652 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

amygdala: 19 nTPM
hippocampal formation: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 16 nTPM
choroid plexus: 16 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 4.17
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
CHAT domain
TTC28, C-terminal domain
CHAT domain
TTC28, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC28 as an antibody target. Whether an autoantibody or antibody against TTC28 could matter depends on whether native TTC28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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