Seroatlas · Human Serome Atlas

CDCA8

Borealin

Also known as: BOR, BOREA_HUMAN, DasraB, FLJ12042, MESRGP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53HL2
Gene
CDCA8
Ensembl
ENSG00000134690
Chromosome
1
Canonical length
280 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytokinetic bridge
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q53HL2|CDCA8
     1  MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR
    61  LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD
   121  EMIVEEEEEE ENERKNLQTA RVKRCPPSKK RTQSIQGKGK GKRSSRANTV TPAVGRLEVS
   181  MVKPTPGLTP RFDSRVFKTP GLRTPAAGER IYNISGNGSP LADSKEIFLT VPVGGGESLR
   241  LLASDLQRHS IAQLDPEALG NIKKLSNRLA QICSSIRTHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 36 nTPM
  • bone marrow: 32 nTPM
  • testis: 22 nTPM
  • tonsil: 21 nTPM
  • lymph node: 18 nTPM
  • rectum: 11 nTPM

Single-cell type

  • early primary spermatocytes: 99 nCPM
  • oocytes: 97 nCPM
  • monocyte progenitors: 84 nCPM
  • erythrocyte progenitors: 69 nCPM
  • differentiating spermatogonia: 56 nCPM
  • late primary spermatocytes: 46 nCPM

Immune cell

  • T-reg: 6 nTPM
  • NK-cell: 4.1 nTPM
  • non-classical monocyte: 3.9 nTPM
  • memory CD4 T-cell: 3.6 nTPM
  • neutrophil: 3.1 nTPM
  • MAIT T-cell: 2.8 nTPM

Brain region

  • basal ganglia: 2.8 nTPM
  • cerebral cortex: 2.4 nTPM
  • amygdala: 2.2 nTPM
  • white matter: 2.1 nTPM
  • hypothalamus: 2 nTPM
  • pons: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.01
gnomAD missense Z
1.02
DepMap mean gene effect
-1.43
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Borealin, N-terminal
  • Cell division protein borealin
  • Borealin, C-terminal
  • Nbl1 / Borealin N terminal
  • Cell division cycle-associated protein 8

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDCA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCA8 as an antibody target. Whether an autoantibody or antibody against CDCA8 could matter depends on whether native CDCA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCA8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDCA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDCA8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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