Leucine-rich repeat and transmembrane domain-containing protein
IPR050541
Definition
This family of proteins includes a variety of members with diverse functions, primarily involved in cellular signaling, synaptic adhesion, and regulation of neuronal activity. Some act as inhibitors, such as those that inhibit TGF-beta signaling or phospholipase A2 activity. Others are involved in the immune response, bone homeostasis, and regulation of the JAK/STAT pathway. Notably, several members function as receptors that mediate axonal growth inhibition and neuronal plasticity, interacting with ligands like RTN4, OMG, and MAG, and are implicated in brain development and synaptic organization. Additionally, some proteins in this family are involved in the negative regulation of viral infection and in the formation of platelet plugs.
26 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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