LRRC17
Leucine-rich repeat-containing protein 17
Also known as: H_RG318M05.3, LRC17_HUMAN, P37NB
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N6Y2
- Gene
- LRRC17
- Ensembl
- ENSG00000128606
- Chromosome
- 7
- Canonical length
- 441 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Vesicles,Cytokinetic bridge
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Predicted to be involved in bone marrow development and negative regulation of osteoclast differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
441 residues, UniProt reviewed canonical sequence.
>Q8N6Y2|LRRC17
1 MRVVTIVILL CFCKAAELRK ASPGSVRSRV NHGRAGGGRR GSNPVKRYAP GLPCDVYTYL
61 HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRTLKNNM FSKFKKLKSL DLQQNEISKI
121 ESEAFFGLNK LTTLLLQHNQ IKVLTEEVFI YTPLLSYLRL YDNPWHCTCE IETLISMLQI
181 PRNRNLGNYA KCESPQEQKN KKLRQIKSEQ LCNEEEKEQL DPKPQVSGRP PVIKPEVDST
241 FCHNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI NQLRPKEFED VHELKKLNLS
301 SNGIEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYNIHY
361 LYYWLKHHYN VHFNGLECKT PEEYKGWSVG KYIRSYYEEC PKDKLPAYPE SFDQDTEDDE
421 WEKKHRDHTA KKQSVIITIV GLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LRRC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 93 nTPM
Expression across tissuesHPA
Tissue
- ovary: 93 nTPM
- blood vessel: 27 nTPM
- gallbladder: 26 nTPM
- cervix: 21 nTPM
- fallopian tube: 16 nTPM
- endometrium: 15 nTPM
Single-cell type
- conjunctival goblet cells: 201 nCPM
- ovarian stromal cells: 182 nCPM
- gastric chief cells: 146 nCPM
- leydig cells: 103 nCPM
- granulosa cells: 72 nCPM
- hepatic stellate cells: 71 nCPM
Immune cell
- eosinophil: 9.9 nTPM
- naive B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 3.6 nTPM
- cerebral cortex: 2.4 nTPM
- choroid plexus: 2.2 nTPM
- midbrain: 2.2 nTPM
- cerebellum: 2 nTPM
- hypothalamus: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.17
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.54
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LRRC17 as an antibody target. Whether an autoantibody or antibody against LRRC17 could matter depends on whether native LRRC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LRRC17 is annotated as secreted, so native LRRC17 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LRRC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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