LRRC66

Protein identityUniProt · HPA

UniProt accession

Q68CR7

Gene

LRRC66

Ensembl

ENSG00000188993

Chromosome

4

Canonical length

880 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

880 residues, UniProt reviewed canonical sequence.

>Q68CR7|LRRC66
     1  MKNLYFRVIT IVIGLYFTGI MTNASRKSNI LFNSECQWNE YILTNCSFTG KCDIPVDISQ
    61  TAATVDVSFN FFRVLLQSHT KKEEWKIKHL DLSNNLISKI TLSPFAYLHA LEVLNLSNNA
   121  IHSLSLDLLS PKSSWVKRHR SSFRNRFPLL KVLILQRNKL SDTPKGLWKL KSLQSLDLSF
   181  NGILQIGWSD FHNCLQLENL CLKSNKIFKI PPQAFKDLKK LQVIDLSNNA LITILPMMII
   241  ALEFPHLVVD LADNNWQCDD SVAVFQNFIS ESWRKKWNVI CNRSIGSEEA NGGTPQSRIS
   301  RETRLPPIHL HRMKSLIRSK AERPQGGRHT GISTLGKKAK AGSGLRKKQR RLPRSVRSTR
   361  DVQAAGKKED APQDLALAVC LSVFITFLVA FSLGAFTRPY VDRLWQKKCQ SKSPGLDNAY
   421  SNEGFYDDME AAGHTPHPET HLRQVFPHLS LYENQTPFWV TQPHPHATVI PDRTLGRSRK
   481  DPGSSQSPGQ CGDNTGAGSG NDGAVYSILQ RHPHAGNREL MSAAQDHIHR NDILGEWTYE
   541  TVAQEEPLSA HSVGVSSVAG TSHAVSGSSR YDSNELDPSL SGEITASLCK MLTHAEAQRT
   601  GDSKERGGTE QSLWDSQMEF SKERQVSSSI DLLSIQQPRL SGARAEEALS AHYSEVPYGD
   661  PRDTGPSVFP PRWDSGLDVT PANKEPVQKS TPSDTCCELE SDCDSDEGSL FTLSSISSES
   721  ARSKTEEAVP DEESLQDESS GASKDNVTAV DSLEENVTFQ TIPGKCKNQE DPFEKPLISA
   781  PDSGMYKTHL ENASDTDRSE GLSPWPRSPG NSPLGDEFPG MFTYDYDTAL QSKAAEWHCS
   841  LRDLEFSNVD VLQQTPPCSA EVPSDPDKAA FHERDSDILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

21 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.82

gnomAD pLI

0

gnomAD missense Z

-1.23

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Leucine-rich repeat domain superfamily
• Leucine-rich repeat and transmembrane domain-containing protein
• Leucine Rich Repeat
• Leucine rich repeat

KeywordsUniProt

• Glycoprotein
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Repeat
• Transmembrane
• Transmembrane helix