Seroatlas · Human Serome Atlas

LRRC53

Leucine-rich repeat-containing protein 53

Also known as: LRC53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM62
Gene: LRRC53
Ensembl: ENSG00000162621
Chromosome: 1
Canonical length: 1247 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1247 residues, UniProt reviewed canonical sequence.

>A6NM62|LRRC53
     1  MLRLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES TNLSLLFNLA
    61  LLSLSRNGIE DVQEDALHGL TMLRTLLLEH NQISSSSLTD HTFSKLHSLQ VLVLSNNALR
   121  TLRGSWFRNT SGLTRLQLDG NQITNLTDSS FGGTNLHSLR YLDLSNNFIS YIGKDAFRPL
   181  PQLQEVDLSR NRLAHMPDVF TPLKQLILLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL
   241  RNAKDLNCQP STAAVAAAQS VLRLSETNCD SKAPNFTLVL KDRSPLLPGP DVALLTVLGF
   301  AGAVGLTCLG LVVFNWKLHQ GKANEHTSEN LCCRTFDEPL CAHEARNYHT KGYCNCHLTQ
   361  ENEIKVMSTV GSRKEMPLLQ ENSHQATSAS ESATLDGSFR NLKKKDRGVG STLFCQDGRL
   421  LHSECSEPPG NMRAFNEAGL LTTYNPRKVQ KLWNLEPGEV QPQTLQHHII RTEDISSDIF
   481  RRRYATPASA LAGESLEKRL TNESWQPPIE KEDNGLHPHR QRHFITSSSS KPCEPEEHYV
   541  QKIVQKNRSK YDDPCGLLKQ SKPRYFQPNN SLICKYVPCE QFEDYMKEKK PNRRQHSKPE
   601  KEQIQINSAI EKFLMSEDNI DLSGLSTKTK KAYSPKRVIF HDPDLVEINR SMMSPKISTP
   661  WKRQKNQSNQ LTKLDVKKFS NTGERNKGEK WFTNSWVLKR KRTPQSDLKG KIKGQNLKLN
   721  LHPFRKVRVH PEKSLSSLPK QCKQVLLPPK KLSKTSETEA KINTVCSADF LQQSESSNYV
   781  RLTSKRLPLK HDSKQTPYYQ RNTKRAPLLS ANNLRVVNQS SIESSCYSAG HIPDGNTSKL
   841  PQPTPTDAEH RHSHSQFSTE QMEDATQLES KVLSYLATTW ENTGSDVLPF QHSRRATDQG
   901  TTESTEHMGQ NVSKTSELNQ FSLSPRNQTQ LLDAHKTDSY NKEYTLDQNE ALQHREQNSS
   961  HAQLENKEKT LMTKPQISHQ IVENCIMDKE ENDVEKKLSK TETYDSSLIP QTQSKNNLSF
  1021  MKTNSIPYQN RIELPKDIST SPVSSQAVWH LTNSSEKGID STNALPRNDG TEALEIKIVG
  1081  KEEKNMLDES KTDSSMLTQI SQMTLKGITK ERQQTWENGT SEKYILHDAS SAEETITAKD
  1141  LSITSSHETQ NRILCSEVDP EVNSNVHNFR EVQNIQPDKD SAHKEGAMTV ETHEALSFLP
  1201  GLKDSFEAEN EVFLVPSRIN EAENSAPKPV LYPPSAEYAT TSPLETE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 0.3 nTPM
heart muscle: 0.1 nTPM
hippocampal formation: 0.1 nTPM
testis: 0.1 nTPM
thymus: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

cardiomyocytes: 772 nCPM
neuroendocrine cells: 13 nCPM
fibro-adipogenic progenitors: 6.1 nCPM
myonuclei: 5.4 nCPM
epicardial cells: 4.5 nCPM
retinal amacrine cells: 4.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 2.7 nTPM
cerebral cortex: 2 nTPM
hippocampal formation: 1 nTPM
medulla oblongata: 1 nTPM
midbrain: 1 nTPM
pons: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.89

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC53 as an antibody target. Whether an autoantibody or antibody against LRRC53 could matter depends on whether native LRRC53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC53 is annotated at the cell surface, where native LRRC53 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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