Seroatlas · Human Serome Atlas

LINGO2

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

Also known as: LERN3, LIGO2_HUMAN, LRRN6C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L985
Gene
LINGO2
Ensembl
ENSG00000174482
Chromosome
9
Canonical length
606 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and synaptic membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q7L985|LINGO2
     1  MLHTAISCWQ PFLGLAVVLI FMGSTIGCPA RCECSAQNKS VSCHRRRLIA IPEGIPIETK
    61  ILDLSKNRLK SVNPEEFISY PLLEEIDLSD NIIANVEPGA FNNLFNLRSL RLKGNRLKLV
   121  PLGVFTGLSN LTKLDISENK IVILLDYMFQ DLHNLKSLEV GDNDLVYISH RAFSGLLSLE
   181  QLTLEKCNLT AVPTEALSHL RSLISLHLKH LNINNMPVYA FKRLFHLKHL EIDYWPLLDM
   241  MPANSLYGLN LTSLSVTNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
   301  ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL SINNNPLACD
   361  CRLLWILQRQ PTLQFGGQQP MCAGPDTIRE RSFKDFHSTA LSFYFTCKKP KIREKKLQHL
   421  LVDEGQTVQL ECSADGDPQP VISWVTPRRR FITTKSNGRA TVLGDGTLEI RFAQDQDSGM
   481  YVCIASNAAG NDTFTASLTV KGFASDRFLY ANRTPMYMTD SNDTISNGTN ANTFSLDLKT
   541  ILVSTAMGCF TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR
   601  FNMKMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINGO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
8.2 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 8.2 nTPM
  • endometrium: 7.3 nTPM
  • thyroid gland: 2.9 nTPM
  • cerebral cortex: 2.5 nTPM
  • hypothalamus: 2.5 nTPM
  • retina: 2.5 nTPM

Single-cell type

  • retinal bipolar cells: 887 nCPM
  • brain inhibitory neurons: 863 nCPM
  • adrenal medulla cells: 851 nCPM
  • brain excitatory neurons: 809 nCPM
  • retinal ganglion cells: 804 nCPM
  • other brain neurons: 722 nCPM

Immune cell

  • NK-cell: 1.3 nTPM
  • total PBMC: 0.6 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hypothalamus: 28 nTPM
  • cerebral cortex: 27 nTPM
  • basal ganglia: 18 nTPM
  • thalamus: 15 nTPM
  • amygdala: 15 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.86
gnomAD missense Z
0.67
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINGO2 as an antibody target. Whether an autoantibody or antibody against LINGO2 could matter depends on whether native LINGO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINGO2 is annotated at the cell surface, where native LINGO2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LINGO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LINGO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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