Seroatlas · Human Serome Atlas

LRRTM3

Leucine-rich repeat transmembrane neuronal protein 3

Also known as: LRRT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VH5
Gene
LRRTM3
Ensembl
ENSG00000198739
Chromosome
10
Canonical length
581 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Involved in regulation of presynapse assembly. Acts upstream of or within positive regulation of amyloid-beta formation. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q86VH5|LRRTM3
     1  MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS
    61  AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR
   121  ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC
   181  RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK
   241  ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
   301  WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI
   361  CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG ATEPGPETDA DAEHISFHKI
   421  IAGSVALFLS VLVILLVIYV SWKRYPASMK QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY
   481  VDYKPTNTET SEMLLNGTGP CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL
   541  SHKSFETNAQ EDTMETHLET ELDLSTITTA GRISDHKQQL A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRTM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 10 nTPM
  • basal ganglia: 5.1 nTPM
  • cerebellum: 3.4 nTPM
  • hypothalamus: 3.3 nTPM
  • amygdala: 3 nTPM
  • pituitary gland: 2.7 nTPM

Single-cell type

  • cardiomyocytes: 7,363 nCPM
  • myonuclei: 1,375 nCPM
  • oligodendrocyte progenitor cells: 839 nCPM
  • epicardial cells: 764 nCPM
  • brain inhibitory neurons: 599 nCPM
  • adrenal medulla cells: 521 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 30 nTPM
  • white matter: 26 nTPM
  • basal ganglia: 25 nTPM
  • amygdala: 20 nTPM
  • cerebellum: 19 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
1.88
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRTM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRTM3 as an antibody target. Whether an autoantibody or antibody against LRRTM3 could matter depends on whether native LRRTM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRTM3 is annotated at the cell surface, where native LRRTM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRTM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRTM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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