Seroatlas · Human Serome Atlas

LRRC38

Leucine-rich repeat-containing protein 38

Also known as: LRC38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VT99
Gene: LRRC38
Ensembl: ENSG00000162494
Chromosome: 1
Canonical length: 294 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables potassium channel activator activity and transmembrane transporter binding activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q5VT99|LRRC38
     1  MRPRAPACAA AALGLCSLLL LLAPGHACPA GCACTDPHTV DCRDRGLPSV PDPFPLDVRK
    61  LLVAGNRIQR IPEDFFIFYG DLVYLDFRNN SLRSLEEGTF SGSAKLVFLD LSYNNLTQLG
   121  AGAFRSAGRL VKLSLANNNL VGVHEDAFET LESLQVLELN DNNLRSLSVA ALAALPALRS
   181  LRLDGNPWLC DCDFAHLFSW IQENASKLPK GLDEIQCSLP MESRRISLRE LSEASFSECR
   241  FSLSLTDLCI IIFSGVAVSI AAIISSFFLA TVVQCLQRCA PNKDAEDEDE DKDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 45 nTPM
adrenal gland: 20 nTPM
tongue: 14 nTPM
cerebellum: 4.3 nTPM
retina: 2.8 nTPM
choroid plexus: 1.8 nTPM

Single-cell type

myonuclei: 117 nCPM
oocytes: 88 nCPM
adrenal cortex cells: 47 nCPM
retinal bipolar cells: 34 nCPM
thymocytes: 17 nCPM
thymic myoid cells: 14 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 7.4 nTPM
midbrain: 4.4 nTPM
medulla oblongata: 4.1 nTPM
spinal cord: 3.7 nTPM
cerebral cortex: 3.6 nTPM
pons: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.14
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.03
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNMA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC38 as an antibody target. Whether an autoantibody or antibody against LRRC38 could matter depends on whether native LRRC38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC38 is annotated at the cell surface, where native LRRC38 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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