Seroatlas · Human Serome Atlas

RTN4RL1

Reticulon-4 receptor-like 1

Also known as: DKFZp547J144, NgR3, NGRH2, R4RL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UN2
Gene: RTN4RL1
Ensembl: ENSG00000185924
Chromosome: 17
Canonical length: 441 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Actin filaments,Midbody
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q86UN2|RTN4RL1
     1  MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPVDSERVF
    61  LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV HLEELDLGDN RQLRTLAPET
   121  FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL
   181  HGNKLWSLGP GTFRGLVNLD RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC
   241  LAPLGALEFL RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
   301  FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR KPGKNCTNPR
   361  NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR KGKCARRTPI RAPSGVQQAS
   421  SASSLGASLL AWTLGLAVTL R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTN4RL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 13 nTPM
skin: 9.1 nTPM
retina: 7.9 nTPM
hippocampal formation: 7.5 nTPM
breast: 6.2 nTPM
pituitary gland: 5.6 nTPM

Single-cell type

late spermatids: 1,255 nCPM
early spermatids: 433 nCPM
cone photoreceptor cells: 162 nCPM
retinal horizontal cells: 146 nCPM
somatotrophs: 104 nCPM
late primary spermatocytes: 101 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 43 nTPM
cerebral cortex: 36 nTPM
amygdala: 26 nTPM
basal ganglia: 23 nTPM
thalamus: 19 nTPM
white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.96
gnomAD missense Z: 1.47
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTN4RL1 as an antibody target. Whether an autoantibody or antibody against RTN4RL1 could matter depends on whether native RTN4RL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTN4RL1 is annotated at the cell surface, where native RTN4RL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTN4RL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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