CHADL

Protein identityUniProt · HPA

UniProt accession

Q6NUI6

Gene

CHADL

Ensembl

ENSG00000100399

Chromosome

22

Canonical length

762 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

Enables collagen binding activity and collagen fibril binding activity. Involved in negative regulation of collagen fibril organization. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

762 residues, UniProt reviewed canonical sequence.

>Q6NUI6|CHADL
     1  MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY QNLTEVPDAI
    61  PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL VAEGAFRGLG RLLLLNLASN
   121  HLRELPQEAL DGLGSLRRLE LEGNALEELR PGTFGALGAL ATLNLAHNAL VYLPAMAFQG
   181  LLRVRWLRLS HNALSVLAPE ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN
   241  PLTYAGEEDG LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG
   301  QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL RPWDLRCPGD
   361  AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC VCVPESRHSS CEGCGLQAVP
   421  RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH LVSLHLQHCG IAELEAGALA GLGRLIYLYL
   481  SDNQLAGLSA AALEGAPRLG YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD
   541  LGRTRALRWV YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL
   601  SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL QKNQLRALPA
   661  LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT CATPPNARGQ RVKAAAAVFE
   721  DCPGWAARKA KRTPASRPSA RRTPIKGRQC GADKVGKEKG RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHADL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

110 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.17

gnomAD pLI

0

gnomAD missense Z

1.96

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of chondrocyte differentiation
• negative regulation of collagen fibril organization

Molecular functions

• collagen binding
• collagen fibril binding
• extracellular matrix structural constituent conferring compression resistance
• signaling receptor activity

Cellular components

• extracellular matrix
• extracellular region

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Leucine-rich repeat domain superfamily
• Leucine-rich repeat and transmembrane domain-containing protein
• Leucine rich repeat

KeywordsUniProt

• Disulfide bond
• Extracellular matrix
• Glycoprotein
• Leucine-rich repeat
• Repeat
• Secreted
• Signal